摘要
目的研究多西紫杉醇/氟尿嘧啶联合顺铂同步放疗治疗局部晚期鼻咽癌近期疗效及安全性。方法60例局部晚期鼻咽癌患者随机分为观察组（TP组）和对照组（PF组）,每组30例。观察组采用多西紫杉醇（TXT）75mg/m^2静滴d1;DDP 25mg/m^2 d1-3静滴;对照组5-Fu 500mg/m^2,静滴,d1-5;DDP25mg/m^2 d1-3静滴;21d为1周期;共2个周期。放疗均采用3D-CRT,靶区剂量67-70Gy/7周。根据RECIST1.1版的标准评价肿瘤近期治疗效果并计算有效率（RR）。按照美国国立癌症研究所通用毒性标准NCI-CTC3.0评价不良反应。结果 60例中57例患者均可评价疗效。有效率（RR）：TP组93.10%,PF组96.42%,二组RR差异无统计学意义（P〉0.05）。二组主要毒副反应包括骨髓抑制、肝功能损害、胃肠道反应和口腔黏膜炎。胃肠道反应和口腔黏膜炎的发生率PF组明显高于TP组（P〈0.05）。结论多西紫杉醇联合顺铂同步放疗治疗晚期鼻咽癌的近期疗效肯定,毒副反应较轻,患者大多可耐受,可作为治疗晚期鼻咽癌的选择。
Objective To evaluate the efficacy and toxicity of concurrent chemoradiotherapy with docetaxel or fluorouracil combined cisplatin for treatment of locally advanced nasopharyngeal carcinoma（NPC）.Methods Totally 60 patients with locally advanced NPC were randomized into the trial group（TP）and the control group（PF）with 30 patients in each group.Patients in TP group were given docetaxel 75mg/m^2 iv d1 combined cisplatin（25mg/m^2 d1-3iv）.Thirty patients in the control group（PF）were given cisplatin（25mg/m^2 d1-3iv）and 5-Fu（500 mg/m^2,iv,d1-5）.Every 3 weeks was a cycle with a total of 2 cycles.Radiotherapy was given in the two groups.Radiation therapy was applied 3D-CRT（Three dimensional conformal RT）,nasopharyngeal target dose was 67-70Gy/7 weeks.Results A total of 57 patients available for efficacy,RR of TP group was 93.10%,RR of PF group was 95.9%,with no significant difference（P0.05）.The main toxicities were myelosuppression,liver damage,gastrointestinal reaction and oral mucositis.The incidence rates of gastrointestinal reaction and oral mucositis in the control group were significantly higher than those in the trial group during treatment（P〈0.01）.Conclusion Docetaxe combined cisplatin in concurrent chemoradiotherapy is effective and tolerable of toxicities in the treatment of locally advanced NPC which can be used as a new option for nasopharyngeal carcinoma.
出处
《中国煤炭工业医学杂志》
2015年第3期386-390,共5页
Chinese Journal of Coal Industry Medicine
