摘要
目的分析调强放射治疗（IMRT）同步化学药物治疗（以下简称化疗）与单独IMRT两种治疗方式联合治疗宫颈癌的近、远期疗效及急、慢性毒副反应的差异,探索IMRT同步化疗治疗宫颈癌的有效性及安全性。方法 62例ⅡA~ⅣA期的宫颈癌患者按治疗方法分为IMRT同步化疗组（同步放化组,34例）与单独IMR T组（单放组,28例）,比较两组的近期疗效及2年总生存率、无进展生存率及急性骨髓抑制、急性胃肠道反应、急性泌尿系反应、慢性放射性肠炎、慢性放射性膀胱炎发生的差异。结果 1同步放化组近期完全缓解率为85.29%（29/34）,2年总生存率为85.29%（29/34）,2年无进展生存率为76.47%（26/34）;单放组近期完全缓解率为78.57%（22/28）,2年总生存率为82.14%（23/28）,2年无进展生存率为71.43%（20/28）,两组比较差异无统计学意义（P〉0.05）。2同步放化组与单放组3、4级的骨髓抑制分别为32.35%和10.71%,差异有统计学意义（P〈0.05）。两组未见3、4级急性胃肠道反应及急性泌尿系反应。慢性放射性肠炎、慢性放射性膀胱炎同步放化组发生率分别为17.65%和5.88%,单放组发生率分别为14.29%、3.57%,两组比较差异无统计学意义（P〉0.05）。结论1IMRT同步化疗较单独IMRT未提高宫颈癌近期疗效及2年生存率,其最终疗效,有待继续随访及进一步高级别临床研究。2IMRT同步化疗与单独IMRT治疗宫颈癌比较,急性胃肠道反应、急性泌尿系反应、慢性放射性肠炎及慢性放射性膀胱炎的发生率未见增加,严重骨髓抑制发生率明显增加。
【Objective】 To search for effective treatment methods combined with intracavitary brachytherapy for cervical cancer by comparing intensity modulated radiotherapy（IMRT） alone with chemotherapy-combined IMRT in terms of 2-year survival rate and complications. 【Methods】 Sixty-two cervical cancer patients in FIGO stage ⅡA-ⅣA were divided into two groups. One group consisted of 34 patients treated with con-current IMRT and chemotherapy（CCRT group）, and the other group consisted of 28 patients treated with IMRT alone（IMRT group）. The two groups were compared in terms of short-term complete response rate, 2-year survival rate and adverse effects including acute bone marrow suppression, acute gastrointestinal reaction,acute urinary tract reaction, chronic radiation enteritis and chronic radiation cystitis. 【Results】 1 The complete response rate in the CCRT group was 85.29% and that in the IMRT group was 78.57%. The 2-year progress-free survival（PFS） rate in the CCRT group was 76.47% and that in the IMRT group was 71.43%.The 2-year survival rate of the CCRT group was 85.29% and that of the IMRT group was 82.14%. The differences were not statistically significant between both groups（P 0.05）. 2 The incidence of grade 3 and 4bone marrow suppression in the CCRT group and IMRT group was 32.35% and 10.71% respectively（P 0.05）. No patient experienced grade 3 or 4 acute gastrointestinal reaction or acute urinary tract reaction in the two groups. The incidences of chronic radiation enteritis and chronic radiation cystitis in the CCRT group were17.65% and 5.88% respectively, whereas those in the IMRT group were 14.29% and 3.57% respectively（P 0.05）. 【Conclusions】 1 The short-term effects and 2-year survival rate in the CCRT group have no significant differences from those in the IMRT group. The long-term effects of the two methods need to be investigated.2 Compared with IMRT alone for the treatment of cervical cancer, the concurrent IMRT and chemotherapy has little influence on the in
出处
《中国现代医学杂志》
CAS
北大核心
2015年第36期68-72,共5页
China Journal of Modern Medicine
关键词
宫颈癌
调强放疗
同步放化疗
2年总生存率
2年无进展生存率
cervical cancer
intensity modulated radiotherapy
concurrent chemoradiotherapy
2-year overall survival rate
2-year progress-free survival rate
