摘要
目的观察白头翁对利福平、异烟肼致肝毒性的保护作用。方法分别测定肝损害组和白头翁组小鼠的肝SGPT ,肝指数 ,肝匀浆丙二醛以及肝细胞镜检 ,并与对照组比较。结果白头翁组具有对抗利福平、异烟肼引起的SGPT增高和肝自由基的产生 ,减轻两者对肝细胞的损害。肝损害组与对照组和白头翁组比较均有显著性差异(P<0.01)。结论白头翁对利福平。
Aim The protective effect of pulastiua chinensis (PC) on hepatic toxic injury induced by combinig rifampin with isoniazid was to be observed in mice. Methods The liver index, level of SGPT, content of MDA of liver homogenate, and degree of liver cell injury were investigated in mice.Results PC could decrease the level of SGPT, the content of MDA and the degree of liver injury (P<0.01). Conclusions PC has the protective effect on hepatic toxic injury induced by combining rifampin with isoniazid in mice.
关键词
白头翁
利福平
异烟肼
肝毒性
肝保护
pulsatiua chinensis
rifampin
isoniazid
protective effect of liver
