摘要
目的:观察人用口服剂量40倍的水红花子对免疫性肝损伤小鼠形态学、生理生化学方面的影响,为临床安全用药提供依据。方法:观察水红花子20g.kg-1.d-1对BCG/LPS致免疫性肝损伤模型小鼠肝脏病理变化及血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性,肝组织超氧化物歧化酶(SOD)、丙二醛(MDA)含量的影响。结果:水红花子组免疫性肝损伤小鼠肝脏病理损伤明显,血清ALT、AST均显著升高(P<0.01),肝组织SOD值明显下降(P<0.05),MDA明显升高(P<0.05)。结论:人用口服剂量40倍的水红花子可提高免疫性肝损伤小鼠的肝脏损伤程度,具有肝毒性,临床不可长期过量服用。
Objective： To explor the cell apoptosis, physiological and biochemistry changes of fructus polygoni orentalis on immune liver injury in mice induced by BCG/LPS. Methods： Fructus polygoni orentalis was given to the mice modle of immune liver injury. The sample of liver and blood were measured. The damage of liver tissues, the activity of ALT, AST and the content of the MDA, SOD was observed. Results： Compared with the model group, the fructus polygoni orentalis coule obviously increase the serum ALT and AST activity and decrease the SOD activity. Pathology results showed that hepatic damnification aggreavated. Conclusion： Liver damage was exacerbated at fructus polygani orentalis treated group at 20g·kg^-1·d^-1 dose. It indicates fructus polygoni orentalis has hepatoxicity. It＇s inappropriate for long time use.
出处
《中西医结合肝病杂志》
CAS
2007年第3期154-155,F0003,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
水红花子
免疫性肝损伤
形态学
小鼠
fructus polygoni orentalis/pharmocological effect
immune liver injury
physiological
mice
