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阿司匹林对心力衰竭患者IL-6和TNF-α的影响 被引量:2

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摘要 目的:探讨阿司匹林对充血性心力衰竭患者血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法:将41例充血性心力衰竭患者随机分为阿司匹林组和对照组,测定两组患者治疗前后血清IL-6和TNN-α浓度。结果:阿司匹林组治疗后IL-6水平较治疗前显著降低(P<0.001),与对照组治疗后相比也显著降低(P<0.001),而对照组自身前后对比TNF-α,IL-6水平均无统计学意义的变化。结论:阿司匹林能减少充血性心力衰竭患者的IL-6水平,减少IL-6对心肌的毒性作用,有益于心力衰竭的治疗,但对TNF-α无明显影响。
作者 刘朝晖 白冰
出处 《中国药业》 CAS 2002年第7期43-44,共2页 China Pharmaceuticals
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