摘要
目的:探讨磷酸肌酸钠辅助治疗新生儿缺氧缺血性心肌损害的疗效及对患儿血清白细胞介素-6(IL-6)和心肌酶的影响。方法:80例缺氧缺血性心肌损害新生儿随机分为观察组和对照组。两组均予维持通气、保暖、维持水电解质及酸碱平衡、维持心率血压、营养支持等常规治疗。在此基础上对照组加用1,6二磷酸果糖250 mg·kg-1,ivd,bid,连用10d;观察组加用磷酸肌酸钠1.0 g溶于0.9%氯化钠注射液100 ml,ivd,qd,连用10 d。观察两组治疗效果和安全性,比较两组患儿血清IL-6和心肌酶的变化。结果:治疗后,两组患儿肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)及乳酸脱氢酶(LDH)及血清IL-6水平均较治疗前明显下降(P<0.05或P<0.01),且观察组治疗后各项指标均明显低于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05);两组患儿治疗期间均未出现严重不良反应。结论:采用磷酸肌酸钠辅助治疗新生儿缺氧缺血性心肌损害疗效显著,能够有效改善患儿的心肌功能,降低心肌酶与血清IL-6水平。
Objective： To discuss the curative effect of phosphocreatine adjuvant treatment on neonatal hypoxic-ischemic myocardi- al lesion and its influence on serum IL-6 and myocardial enzyme. Methods： Totally 80 cases of newborns with hypoxic-ischemic myo- cardial lesion were divided into the observation group and the control group at random. The two groups were given the routine medical treatment, including maintenance of ventilation, warmth, water-electrolyte and acid-base balance, heart rate, blood pressure, nutrition support and etc, while the newborns in the control group were additionally given 250 mg · kg-1 1,6 diphosphate （FDP）, ivgtt bid, for 10 days, while those in the observation group, were additionally given 1.0g phosphocreatine dissolved in 100 ml 0.9% normal saline （NS） on the basis of the treatment of the control group, ivgtt qd, for 10 days. The clinical curative effect and security were observed and the changes of serum IL-6 and myocardial enzyme in the two groups were compared. Results： The levels of LDH, CK, CK-MB and serum IL-6 in the two groups were obviously declined when compared with those before the treatment （ P 〈 0.05 or P 〈 0.01 ）, and the declining rate of the observation group was higher than that of the control group （P 〈 0.05 ）. The total clinical efficiency of the ob- servation group was higher than that in the control group after the medical treatment （P 〈 0.05 ）, and no serious untoward effect ap- peared in the two groups during the medical treatment. Conclusion： Phosphocreatine has significant curative effect on neonatal hy- poxic-ischemic myocardial lesion, which can effectively improve myocardial function of newborns and reduce myocardial enzyme and se- rum IL-6 levels.
出处
《中国药师》
CAS
2016年第6期1123-1125,共3页
China Pharmacist
