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动态优化方法在何首乌提取工艺优化中应用研究 被引量:3

Studies on Application of Dynamic Optimization Extraction Method in Extraction Process Optimization of Polygonum Muliflorum Thumb.
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摘要 目的采用动态优化方法,优化何首乌的提取工艺。方法 :以2,3,5,4’-四羟基二苯乙烯-2-O-β-D-葡萄糖苷、大黄素-8-O-β-D-葡萄糖及大黄素甲醚-8-O-β-D-葡萄糖含量为指标,结合指纹图谱相似度分析,比较何首乌正交优化提取工艺和动态优化提取工艺所得提取物的一致性。结果动态优化提取工艺为10倍水提3次,第一次90min,第二次70min,第三次50min。两种工艺所得提取物中指标成分含量及浸膏得率的RSD均<5%,指纹图谱相似度为100%,表明两种提取物基本一致;动态优化提取工艺比正交优化提取工艺节约61%的时间,能大幅降低成本。结论动态优化方法在何首乌的提取工艺上是可行的,并能节约生产成本。 OBJECTIVE To optimize the extraction method of Polygonum multiflorum Thumb.by applying dynamic optimization extraction method(DOEM).METHODS Stilbene glucoside,emodin-8-O-β-D-glucose and emodin methyl ether-8-O-β-D-glucose were regarded as indexes,two extraction processes,orthogonal design and DOEM,were both employed to optimize extraction of Polygonum multiflorum thumb.,and then were compared by concents of marker components,extract yield and similarity evaluation of fingerprint.RESULTS The dynamic optimization extraction process was extracting for 3 times with 10-folds of water,and extracting time was 90,70,50 minutes in turn.Relative standard deviations of concentration of marker components and total solids yield in these extraction processes were less than 5% with a 100% of similarity in fingerprint.The DOEM process could save 61% of the extraction time and greatly reduce the cost,which was superior to the orthogonal design optimization process.CONCLUSION Dynamic optimization extraction method on the extraction process of Polygonum multiflorum Thumb.is feasible,and can save the cost of production.
出处 《海峡药学》 2015年第3期52-55,共4页 Strait Pharmaceutical Journal
关键词 何首乌 动态优化法 二苯乙烯苷 大黄素-8-O-β-D-葡萄糖 大黄素甲醚-8-O-β-D-葡萄糖 Polygonum muliflorum Thunb. Dynamic optimization extraction method Stilbene glucoside Emodin-8-O-β-D-glucose Emodin methyl ether-8-O-β-D-glucose
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