摘要
目的:了解贵阳地区儿童感染幽门螺杆菌(Helicobacter pylori,H.pylori)临床分离株对常用抗H.pylori抗生素甲硝唑、克拉霉素、阿莫西林等的体外敏感性,以指导临床用药根除H.pylori感染.方法:收集2011-10/2014-06贵阳市儿童医院行胃镜检查的患儿胃黏膜标本进行H.pylori分离培养,对分离鉴定后的菌株采用界值法进行甲硝唑、克拉霉素、阿莫西林、左氧氟沙星的敏感性试验.结果:从434例患儿胃黏膜中培养出H.pylori63株(14.5%),63例H.pylori菌株中3株为敏感菌株,60株为耐药菌株,其对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星的耐药率分别为57.1%、85.7%、38.1%、90.5%.二重、三重、四重耐药率分别为90.5%(57/63)、57.1%(36/63)、38.1%(24/63).结论:贵阳地区儿童感染H.pylori对阿莫西林敏感性高于对其他常用药物的敏感性;对左氧氟沙星和克拉霉素的耐药率较高,并且多重耐药率较高.
AIM： To investigate the antibiotic resistanceof Helicobacter pylori（H. pylori） clinical isolates from children in Guiyang area.METHODS： H. pylori strains were isolated from children who underwent gastroduodenoscopy at Guiyang Children＇s Hospital from October 2011 to June 2014, and were further incubated in microaerobic condition. The susceptibility of H. pylori to metronidazole, elarithromycin, amoxicillin and levofloxacin was tested by the breakpoint method. RESULTS： A total of 63 H. pylori strains were isolated from 434 children. Sixty isolates were drug resistant, and only 3 were sensitive strains. Of all isolates, 57.1% were resistant to metronidazole, 85.7% resistant to clarithromycin, 38.1% to amoxicillin and 90.5% to levofloxacin. The dual, triple and quadruple resistance percentages were 90.5%（57/63）, 57.1%（36/63） and 38.1%（24/63）, respectively. CONCLUSION ： Resistance rate against amoxicillin is lower than those against other antibiotics. Resistance rate to levofloxacin is higher. Multi-drug resistance is serious in Guiyang area.
出处
《世界华人消化杂志》
CAS
2015年第8期1369-1373,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81460314
贵州省卫生厅基金资助项目
No.gzwkj2011-1-017~~
关键词
幽门螺杆菌
药敏试验
耐药性
Helicobacter pylori
Antibiotic sensitivity testing
Resistance
