摘要
目的:观察盐酸多奈哌齐联合尼莫地平治疗血管性痴呆的临床疗效。方法:血管性痴呆患者60例,随机分为观察组和对照组,对照组服用盐酸多奈哌齐(5 mg/d),每晚临睡前口服;观察组在对照组的用药基础上联用尼莫地平片30 mg,3次/d,疗程8周;采用简易精神状态检查表(MMSE)、临床痴呆量表(CDR)及日常生活自理量表(ADL)于治疗前、治疗4周及治疗8周时对2组患者进行评分,评价疗效,同时观察两组不良反应。结果:观察组治疗后MMSE、CDR及ADL评分均较治疗前明显改善,差异有统计学意义(P<0.01,P<0.05,P<0.01);对照组治疗后MMSE、CDR评分较治疗前明显改善,差异有统计学意义(P<0.01,P<0.05),ADL分数虽较治疗前减少,但差异无统计学意义(P>0.05),两组均无严重不良反应。结论:盐酸多奈哌齐联合尼莫地平治疗血管性痴呆的疗效优于单独使用盐酸多奈哌齐。
Objective： To observe the clinical curative effect of donepezil combined with nimodipine in the treatment of vascular dementia. Methods： Sixty patients with vascular dementia were randomly divided into observation group（ donepezil combined with nimodipine） and control group（ single donepezil group）,the patients in control group were given oral donepezil（ 5mg/d） every night before going to sleep; based on the treatment of control group,the patients in observation group was treated with nimodipine tablets 30 mg tid for 8 weeks,all the subjects were followed up every 4 weeks. Mini mental state examination（ MMSE）,the clinical dementia rating scale（ CDR） and daily living scale（ ADL）were used to evaluate the curative effect. Results： MMSE,CDR and ADL scores in the observation group were significantly improved after treatment（ P〈0. 01,P〈0. 05,P〈0. 01）. MMSE,CDR scores in the control group were significantly improved after treatment（ P〈0. 01,P〈0. 05）,ADL score was decreased after treatment in control group,but the difference was not statistically significant（ P〈0. 05）. There was no serious adverse reaction in both the two groups. Conclusions： The therapeutic effect of donepezil combined with nimodipine in the treatment of vascular dementia is better than single use of donepezil hydrochloride.
出处
《贵阳医学院学报》
CAS
2015年第3期291-293,共3页
Journal of Guiyang Medical College
