摘要
目的探讨鼠神经生长因子在中度与重度老年痴呆患者中的临床应用效果。方法将46例中度老年痴呆患者随机分为中度实验组与中度对照组,将33例重度老年痴呆患者随机分为重度实验组与重度对照组。对实验组给予常规治疗,并每日滴注20μg鼠神经生长因子,而对照组仅给予常规治疗。在治疗前及治疗6周和12周后进行简易智能状态量表(MMSE)、临床痴呆评定量表(CDR)和日常生活自理量表(ADL)评分,并比较各组的评分结果,同时观察不良反应。结果中度与重度老年痴呆患者在接受6周与12周治疗后,实验组MMSE、CDR、ADL评分均优于对照组(P<0.05),而中度实验组改善的效果要好于重度实验组(P<0.05)。结论鼠神经生长因子对治疗中度、重度老年痴呆有效,但对中度老年痴呆的疗效更好。
Objective To study the effect of mouse nerve growth factor （mNGF） on elderly patients with moderate or severe senile dementia. Methods Forty-six patients with moderate senile dementia were randomly divid- ed into moderate experimental group and moderate control group, while 33 patients with severe senile dementia were randomly divided into severe experimental group and severe control group. The experimental group （moderate experi- mental group and severe experimental group） was injected with 20 μg mNGF everyday besides conventional therapy, while the control group （moderate control group and severe control group） received conventional therapy. MMSE, Clinical Dementia Rating Scale （CDR） and Activities of Daily Livings Scale （ADL） scores were assessed before treatment and after 6 and 12 weeks of treatment. Results After 6 and 12 weeks of treatment, the scores of MMSE, CDR and ADL in the experimental group significantly improved, compared with those of the control group （P〈0.05）. And the improved effect of moderate experimental group were better than severe experimental group （P〈0.05）. Conclusion mNGF is effective to treat elderly patients with moderate or severe dementia, and it has better efficacy on moderate senile dementia.
出处
《海南医学》
CAS
2014年第7期959-961,共3页
Hainan Medical Journal
关键词
鼠神经生长因子
中度
重度
老年痴呆
Mouse nerve growth factor （mNGF）
Moderate
Severe
Senile dementia
