摘要
卵巢癌是一种恶性程度高、发病隐匿的妇科恶性肿瘤,死亡率居妇科恶性肿瘤之首。多数卵巢癌诊断时已是晚期。MMP-9即基质金属蛋白酶-9,是重要的蛋白水解酶,参与肿瘤侵袭与转移的多步骤过程。大量研究证明:MMP-9能降解细胞外基质的多种成分,包括明胶和基底膜的Ⅳ型胶原,Ⅳ型胶原是构成阻止肿瘤侵袭屏障的重要成分,同时MMP-9还可以促进肿瘤细胞的生长,减少肿瘤细胞凋亡,促进肿瘤血管的生成,在卵巢癌的侵袭与转移中发挥重要作用。多种因子被发现与卵巢癌有关,研究其机制时发现与MMP-9的表达水平相关,下调MMP-9的表达水平成为卵巢癌新的治疗方法。本文对MMP-9及其相关因子在卵巢癌中的研究进展进行综述,并对其在卵巢癌的研究与应用前景作出展望。
Ovarian caner is the most lethal malignancy of all gynecological cancers. The majority of ovarian cancers are diagnosed in their advanced stage, matrix metalloproteinase - 9 （ MMP - 9） is an important proteinase, involved in invasion and metastasis that is thought to be a multistep process. It has been demonstrated that MMP -9 can degrade various components of the extracellular matrix, gelatin and type IV collagen included. Type IV collagen is a major component of the basement membrane which constitutes an important barrier to tumor cell invasion. MMP -9 can pro- mote tumor growth and angiogenesis, reduce the apoptosis and play an critical role in invasion and metastasis in ovari- an cancer. Many factors associated with ovarian cancer have been discovered that their function through the mecha- nisms of MMP - 9 expression, downregulation of MMP - 9 is an attractive therapeutic approach in the future. This arti- cle gives a review on the progess of MMP -9 and its relevant factors in ovarian cancer.
出处
《现代肿瘤医学》
CAS
2015年第8期1159-1162,共4页
Journal of Modern Oncology
关键词
基质金属蛋白酶-9
卵巢癌
侵袭与转移
治疗
matrix metalloproteinase - 9
ovarian caner
invasion and metastasis
treatment
