摘要
Mir-217是miRNAs家族的重要成员,在高糖培养的肾小球系膜细胞中表达量升高.Sirt1是一个NAD＋调节的脱乙酰酶,既往在衰老性疾病中研究较多,近期发现其在糖尿病肾病中起到抗炎、抗氧化、抗纤维化等保护作用.研究指出,在多种病理条件下mir-217通过直接作用于Sirt1mRNA的3＆#39;非翻译区,显著抑制Sirt1蛋白表达,因此mir-217/Sirt1通路可能在糖尿病肾病的发生、发展中起关键作用.
Mir-217 is an important member of the miRNAs family overexpressed in high glucose cultured glomerular mesangial cells.Sirt1 is an NAD （＋）-dependent deacetylase,which has obtained great focus on the research of aging.Recent researches reported that Sirt1 has protective functions in diabetic nephropathy such as anti-inflammation,anti-oxidance and anti-fibrosis.In a variety of pathological conditions,mir-217 directly acts on the 3 ＆#39; translation section of Sirt1 mRNA,and inhibits expression of Sirt1 protein.Thus,mir-217/Sirt1 pathway may play a key role in the occurrence and development of diabetic nephropathy.
出处
《国际内分泌代谢杂志》
2015年第2期124-126,共3页
International Journal of Endocrinology and Metabolism
基金
辽宁省科学技术计划项目（2011225017）
辽宁省百千万人才工程资助项目（2011921037）
