摘要
目的：探讨心肌肌钙蛋白I在而儿童病毒性心肌炎诊断和病情发展方面的临床实用价值，并分析其与肌酸激酶同工酶间的关系，以此总结心肌肌钙蛋白I及肌酸激酶同工酶对儿童病毒性心肌炎治疗方面的影响作用，为临床实践提供有效依据。方法：采用胶乳增强免疫比浊法和酶速率法测定48例病毒性心肌炎患儿、48例非心肌炎患儿和48例体检健康儿童的血清肌钙蛋白I（cTnI）和肌酸激酶同工酶（CK-MB）的阳性率，比较其是否具有统计学差异；并48例对病毒性心肌炎患儿进行病情观察，判定肌钙蛋白I阳性率与心内膜心肌活检一致性，分别于入院1周、2周、3周以及3月后监测心肌酶谱和血清肌钙蛋白I，对其进行动态分析，比较心电图（ECG）、cTnI、CK-MB与病程变化的关系。结果：病毒性心肌炎患儿组cTnI阳性率为75.4%、CK-MB阳性率为58.3%，非心肌炎组cTnI阳性率为8.3%、CK-MB阳性率为31.3%，健康组cTnI阳性率和CK-MB阳性率均为0.0%，三组具有明显统计学差异。病毒性心肌炎患儿入院1周cTnI阳性率为73.3%、CK-MB阳性率为58.3%，第二周cTnI阳性率为60%、CK-MB阳性率为20%，第三周cTnI阳性率为33.3%、CK-MB阳性率为33.3%，第三月cTnI阳性率和CK-MB阳性率均为0.0%。cTnI阳性率与心内膜心肌活检阳性率无统计学差异，且cTnI阳性患儿的治愈率明显低于cTnI阴性患儿。结论：肌钙蛋白I在儿童病毒性心肌炎的诊断中具有重要实用价值基本可以取代传统心肌酶谱测定，在儿童病毒性心肌炎的病情观察中也具有重要意义。
Objective：To investigate the myocardial troponin I and children viral myocarditis diagnosis and clinical practical value with the development of the disease, and analyze it with the relationship between creatine kinase isoenzyme, to summarize the myocardial troponin I and creatine kinase isozyme effect in treatment of children viral myocarditis, provide effective basis for clinical practice. Methods：Latex particle-enhanced turbidimetric and enzyme rate method in 48 cases of children with viral myocarditis, 48 cases of children with suspicious viral myocarditis, and 48 cases of medical healthy children serum troponin I （cTnI） and creatine kinase isoenzyme （CK - MB） positive rate, to compare whether the statistically difference; And 48 cases of children with viral myocarditis observation, determine the positive predictive value of troponin I and endocardium myocardial biopsy, consistency in hospital 1 week, 2 weeks, 3 weeks and 3 months monitoring myocardial enzymes and serum troponin I, on the dynamic analysis, compare the electrocardiogram （ECG）, cTnI, CK - MB relationship with the clinical course.Results：Children with viral myocarditis group cTnI positive rate was 75.4%, the CK-MB positive rate was 58.3%, the cTn myocarditis group I positive rate was 8.3%, the CK-MB positive rate was 31.3%, the health group cTnI positive rate and CK - MB positive rate was 0.0%, three groups has significant statistical difference. Children with viral myocarditis in hospital 1 week cTnI positive rate was 73.3%, the CK-MB positive rate was 58.3%, the second week of cTn, I positive rate was 60%, the CK-MB positive rate was 20%, the third week of cTn, I positive rate was 33.3%, the CK-MB positive rate was 33.3%, the first of march cTnI positive rate and CK-MB positive rate were 0.0%. CTn I positive rate and endocardial myocardium biopsy were no statistical differences, and cTn, I positive with the cure rate significantly lower than the cTnI negative. Conclusions：The troponin I in has the important practical value
出处
《医学检验与临床》
2015年第1期42-44,共3页
Medical Laboratory Science and Clinics
关键词
肌钙蛋白I
儿童
心肌酶谱
病毒性心肌炎
Troponin I
Children
Myocardial enzyme spectrum
Viral myocarditis
