摘要
Background：Neuroimaging studies have found that functional changes exist in patients with Parkinson＇s disease （PD）.However,the majority of functional magnetic resonance imaging （fMRI） studies in patients with PD are task-related and cross-sectional.This study investigated the functional changes observed in patients with PD,at both baseline and after 2 years,using resting-state fMRI.It further investigated the relationship between whole-brain spontaneous neural activity of patients with PD and their clinical characteristics.Methods：Seventeen patients with PD underwent an MRI procedure at both baseline and after 2 years using resting-state fMRI that was derived from the same 3T MRI.In addition,20 age-and sex-matched,healthy controls were examined using resting-state fMRI.The fractional amplitude of low-frequency fluctuation （fALFF） approach was used to analyze the fMRI data.Nonlinear registration was used to model within-subject changes over the scanning interval,as well as changes between the patients with PD and the healthy controls.A correlative analysis between the fALFF values and clinical characteristics was performed in the regions showing fALFF differences.Results：Compared to the control subjects,the patients with PD showed increased fALFF values in the left inferior temporal gyrus,right inferior parietal lobule （IPL） and right middle frontal gyrus.Compared to the baseline in the 2 years follow-up,the patients with PD presented with increased fALFF values in the right middle temporal gyrus and right middle occipital gyrus while also having decreased fALFF values in the right cerebellum,right thalamus,right striatum,left superior parietal lobule,left IPL,left precentral gyrus,and left postcentral gyrus （P 〈 0.01,after correction with AlphaSim）.In addition,the fALFF values in the right cerebellum were positively correlated with the Unified PD Rating Scale （UPDRS） motor scores （r =0.5 l,P 〈 0.05,uncorrected） and the change in the UPDRS motor score （r =0.61,P 〈 0.05,u
Background：Neuroimaging studies have found that functional changes exist in patients with Parkinson＇s disease （PD）.However,the majority of functional magnetic resonance imaging （fMRI） studies in patients with PD are task-related and cross-sectional.This study investigated the functional changes observed in patients with PD,at both baseline and after 2 years,using resting-state fMRI.It further investigated the relationship between whole-brain spontaneous neural activity of patients with PD and their clinical characteristics.Methods：Seventeen patients with PD underwent an MRI procedure at both baseline and after 2 years using resting-state fMRI that was derived from the same 3T MRI.In addition,20 age-and sex-matched,healthy controls were examined using resting-state fMRI.The fractional amplitude of low-frequency fluctuation （fALFF） approach was used to analyze the fMRI data.Nonlinear registration was used to model within-subject changes over the scanning interval,as well as changes between the patients with PD and the healthy controls.A correlative analysis between the fALFF values and clinical characteristics was performed in the regions showing fALFF differences.Results：Compared to the control subjects,the patients with PD showed increased fALFF values in the left inferior temporal gyrus,right inferior parietal lobule （IPL） and right middle frontal gyrus.Compared to the baseline in the 2 years follow-up,the patients with PD presented with increased fALFF values in the right middle temporal gyrus and right middle occipital gyrus while also having decreased fALFF values in the right cerebellum,right thalamus,right striatum,left superior parietal lobule,left IPL,left precentral gyrus,and left postcentral gyrus （P 〈 0.01,after correction with AlphaSim）.In addition,the fALFF values in the right cerebellum were positively correlated with the Unified PD Rating Scale （UPDRS） motor scores （r =0.5 l,P 〈 0.05,uncorrected） and the change in the UPDRS motor score （r =0.61,P 〈 0.05,u
