摘要
目的合成盐酸氯普鲁卡因并改进工艺。方法以2-氯-4-硝基苯甲酸为起始物料,经过还原、酯化、成盐3步反应制得盐酸氯普鲁卡因。结果目标物经IR、1H-NMR、13C-NMR和MS确证结构,反应总收率达到73.9%,纯度为99.76%。结论该合成路线操作简便、反应条件温和,适于工业化生产。
OBJECTIVE To synthesis chloroprocainehydrochloride and optimize the reaction conditions.METHODSThe chloroprocainehydrochloride was synthesized from 2-chloro-4-nitrobenzoic acid via reduction,esterification and salification.RESULTS The structure of product was identified by IR,1H-NMR,13C-NMR and MS,the total yield was 73.9% and the HPLC purity was 99.76%.CONCLUSION The synthetic process is simple,easy to control and suitable for industrial production.
出处
《中国现代应用药学》
CAS
CSCD
2015年第3期304-306,共3页
Chinese Journal of Modern Applied Pharmacy
