摘要
目的合成盐酸帕洛诺司琼。方法以1,2,3,4-四氢-1-萘甲酸为起始原料,经拆分、胺化、还原、关环、成盐制得盐酸帕洛诺司琼。结果目标化合物经核磁共振氢谱、质谱、红外及元素分析等确证其化学结构,总收率9.4%。结论本工艺操作简便,成本较低,反应条件温和,产品质量易控制。
Objective To synthesize palonosetron hydrochloride.Methods Starting from 1,2,3,4-tetrahydro-1-naphthoic acid,palonosetron hydrochloride was prepared via a series of steps such as resolution,amination,reduction,cyclization and salt formation.Results The structure of palonosetron hydrochloride was verified by 1HNMR,MS,IR and element analysis.The total yield of palonosetron hydrochloride was 9.4%.Conclusion A simple,easily controlled and cost-saving process for the synthesis of palonosetron hydrochloride can be attainable under mild reaction conditions.
出处
《食品与药品》
CAS
2010年第3期86-89,共4页
Food and Drug
关键词
盐酸帕洛诺司琼
合成
止吐药
palonosetron hydrochloride synthesis antiemetic
