摘要
目的 观察地佐辛联合小剂量舒芬太尼用于防治全麻苏醒期躁动的临床效果。方法 60例ASAⅠ或Ⅱ级在全麻下行胃癌根治术患者,随机分为地佐辛0.1、0.2mg/kg组(D1、D2组)和对照组(C组),每组20例。术毕前30min联合舒芬太尼0.1μg/kg缓慢静注。观察各组的HR、MAP、SpO2、躁动评分(RS)、Ramsay镇静评分(RSS)。观察时点:术前(T1)、拔管时(T2)、拔管后10min(T3)、20min(T4)。并记录拔管时间、苏醒时间、全麻后身体舒适度评分(BCS)和不良反应。结果 T2、T3、T4时D1、D2组RS分值均低于C组(P<0.05)。T2、T3、T4时D1、D2组RSS分值均高于C组(P<0.05),D2组RSS分值又高于D1组(P<0.05)。D1、D2组BCS分值均高于C组(P<0.05),D1、D2组躁动发生率也低于C组(P<0.05)。C、D1组拔管时间和苏醒时间明显少于D2组(P<0.05),而且C、D1组无1例发生呼吸抑制,明显低于D2组(P<0.05)。结论 地佐辛0.1mg/kg联合舒芬太尼0.1μg/kg能很好地预防术后躁动的发生。
Objective To observe the effect of dezocine combined low-dose sufentanil on preventing the emergence agitation during anesthetic recovery. Methods Sixty ASA class Ⅰ or Ⅱ patients undergoing radical operations for carcinoma of stomach under general anesthesia were randomized into three groups of D1, D2 and C with 20 cases each. Thirty minutes before the end of surgery, combined with sufentanil 0.1μg/kg, dezocine 0, 0.1, 0.2 mg/kg were administered in groups C, D1, D2 respectively. HR, MAP, SpO 2, Restlessness Score（RS） and Ramsay Sedative Score（RSS） were recorded at preoperative（T1）, during extubation（T2） and 10 min（T3）, 20 min（T4） after extubation. Moreover, extubation time, awake time, Body Comfort Score（BCS） and side reactions were observed. Results The RS of group C were apparently higher than group D1 and D2 at T2-T4（P〈0.05）. The RSS of group C were apparently lower than group D1 and D2 at T2-T4（P〈0.05）, and the RSS of group D1 were apparently lower than group D2 at T2-T4（P〈0.05）. The BCS of group C were apparently lower than group D1 and D2（P〈0.05）.Compared to group D2, extubation time, awake time was shorter in group C and D1（P〈0.05）. The main side effects of group D2 was the inhibition of respiratory. Conclusion The application of 0.1 mg/kg dezocine combined 0.1 μg/kg sufentanil can safely and perfectly prevent the emergence agitation during anesthetic recovery.
出处
《中国医药指南》
2015年第6期20-21,共2页
Guide of China Medicine
关键词
地佐辛
瑞芬太尼
舒芬太尼
苏醒期躁动
预防
Dezocine
Remifentanil
Sufentanil
Emergence agitation
Prevention
