摘要
目的观察氟比洛芬酯预防老年患者全麻苏醒期躁动的作用。方法60例ASA Ⅰ～Ⅱ级择期上腹部手术老年患者，随机分为对照组（n=15），试验组1（切皮前静脉给予氟比洛芬酯50mg，n=15），试验组2（缝皮时静脉给予氟比洛芬酯50mg，n=15），试验组3（切皮前及术毕缝皮时均静脉给予氟比洛芬酯50mg，n=15）。观察手术时间、麻醉维持时间、清醒时间及拔管时间；监测苏醒期心率（HR）、平均动脉压（MAP）、血氧饱和度（SpO2）及躁动评分、镇静评分身体舒适度评分；术后24h随访副作用。结果4组患者性别、年龄、体重、手术时间、拔管时间及苏醒时间差异无统计学意义。与对照组相比，各试验组在术毕后各时点的HR，MAP均显著降低（P〈0．05）。4组患者在各观察时点的SpO2无统计学差异。各试验组在各观察时点的躁动评分均显著低于对照组（P〈0．05），Ramsay镇静评分均显著高于对照组（P〈0．05）。拔管后10min，各试验组的身体舒适度评分均显著高于对照组（P〈0．05）。4组患者术后24h内仅试验组1有1例患者出现皮肤瘙痒，试验组3中有1例患者出现胃部不适及呕吐。结论静注氟比洛芬酯能安全有效预防老年患者躁动。
Objective To evaluate the preventive effect of flurbiprofen axetil on restlessness during analepsia from general anesthesia in elderly patients. Methods Sixty elderly patients with ASA grade Ⅰ -Ⅱ , undergoing selective operation at epigastrie zone were randomly divided into 1 control group and 3 test groups （n=15）. Flurbiprofen axetil （50 mg） was administrated before incising the skin （test group 1 ）, before suturing the skin （test group 2） or both before incising and suturing the skin （test group 3）. HR, MAP, SpO2, Restlessness Score, Ramsay Sedative Score and Body Comfort Score were monitored and assessed during analepsia. Adverse effects were subsequently visited after operation. Results There is no difference in gender ration, age, body weight, duration of operation and anesthesia, time for extubation and analepsia among four groups. HR and MAP in test groups were lower than that in control group （P〈0.05）, and no difference in SpO2 was observed among four groups. Restlessness Score was apparently lower and Ramsay Sedative Score, Body Comfort Score was significantly higher in test groups than in control group （P〈0.05）. During post-operative 24h, skin itch and vomiting occurred in one case each from test group 1 and test group 3, respectively. Conclusion It is safe and feasible of using flurbiprofen axetil to prevent restlessness during analepsia in elderly patients.
出处
《国际麻醉学与复苏杂志》
CAS
2009年第2期124-126,176,共4页
International Journal of Anesthesiology and Resuscitation
关键词
氟比洛芬酯
老年患者
全麻
苏醒
躁动
Flurbiprofen axetil
Elderly patients
General anesthesia
Analepsia
Restlessness
