摘要
目的探讨212例下呼吸道鲍曼不动杆菌感染分布表现、耐药性特点及多重耐药菌的易感因素。方法 2010年4月至2012年4月我院收治212例下呼吸道感染患者,对其分离出的212株鲍曼不动杆菌进行调查,分析其分布、耐药性及多重耐药性患者和非多重耐药性患者两者间的易感因素。结果 212例下呼吸道感染患者分离出鲍曼不动杆菌212株,其中多重耐药80株,主要分布在重症监护病房(ICU),其次为呼吸内科、神经内科等。2010-2012年多重耐药的鲍曼不动杆菌构成比例分别36.2%、36.7%、39.2%;其特点是对多粘菌素B最为敏感,其次是替加环素;对含有β-内酰胺酶抑制剂复方制剂抗菌类药物均表现为明显的耐药性。结论鲍曼不动杆菌对多粘菌素B最为敏感,其次是替加环素,对碳青霉素烯类抗菌药物其耐药性呈现逐步上升的趋势;使用不同抗菌药物、并发心脑血管疾病以及病情变化成为多重耐药菌感染的主要易感因素。
Objective To shed light on the distribution, resistance characteristics and risk factors of multi-resistant bacteria, and to give clinical guidance for the use of antimicrobial drugs.Methods 2010 April to 2012 April in our hospital 212 cases of patients with lower respiratory tract infection,on 212 strains of Bauman Acinetobacter were investigated,analyzed the distribution,drug resistance and multi drug resistance patients and non multiple drug resistance patients between the susceptible factors.Results 212 cases of lower respiratory tract infection in patientswith isolated Bauman Acinetobacter strain 212,among them 80 strains of multiple drug resistance,mainly distributed in the intensive care unit（ICU）,followed by respiratory department of Internal Medicine Department of internal medicine, nerve.2010-2012 years of multidrug resistant Acinetobacter proportion of Bauman were 36.2%,36.7%,39.2%; characteristics of polymyxin B was the most sensitive,followed by tigecycline;containing beta lactamase inhibitor compound preparation of antibacterial drugs showed obvious resistance.Conclusion Bauman Acinetobacter to polymyxin B was the most sensitive,followed by tigecycline on carbapenem antibacterial drug drug resistance has gradually on the rise;the use of different antibiotics,and cardio cerebrovascular disease and illness change become multi drug resistant bacteria infection major predisposing factors.
出处
《中国药物经济学》
2015年第2期173-175,共3页
China Journal of Pharmaceutical Economics
关键词
下呼吸道感染
鲍曼不动杆菌
分布
耐药性
Lower respiratory tract infections
Acinetobacter Baumannii
Distribution
Drug resistance
