摘要
溃疡性结肠炎(UC)是一种病因尚不十分清楚的慢性非特异性肠道炎症性疾病,其发病与遗传、环境、免疫等因素密切相关。流行病学资料表明UC在戒烟者和从不吸烟者中更为多见,目前吸烟者UC患病率较低且临床症状较轻。研究显示吸烟可能通过调节T细胞和单核巨噬细胞功能以及Th1/Th2免疫平衡,起到改善UC肠道炎症的作用。本文就吸烟对UC发病以及患者免疫功能的影响作一综述。
Ulcerative colitis （UC） is a chronic non-specific inflammatory bowel disease of uncertain etiology; genetic, environmental factors and immune disorders are thought to be involved in the pathogenesis of UC. Epidemiological studies revealed that UC was frequently diagnosed in ex-smokers and non-smokers, whereas the prevalence and clinical symptoms of UC were reduced in current smokers. It has been demonstrated that smoking may exert anti-inflammatory effect in UC by modulating T cells and mononuclear macrophages and balancing Thl/Th2 immune responses. In this review article, the effects of smoking on occurrence and immune function of UC were summarized.
出处
《胃肠病学》
2015年第1期49-51,共3页
Chinese Journal of Gastroenterology
