摘要
目的：探讨前列腺腺癌患者年龄与Gleason评分（Gleason score,GS）的相关性。方法：研究674例患者年龄和GS均值以及不同组别均值;不同GS和年龄组别所占比例;年龄与GS、主要分级以及次要分级的相关性。结果：患者年龄25-96（70.22±8.26）岁,Gleason 6分、7分、8分、9分及10分组年龄分别为（69.06±8.35）、（70.55±8.16）、（70.99±6.54）、（71.56±9.18）岁及（72.79±11.36）岁。GS（7.08±1.09）分,主要分级（3.54±0.72）级,次要分级（3.53±0.66）级;〈60、60-69、70-79及≥80岁组GS分别为（6.86±1.10）、（6.99±1.10）、（7.08±1.04）分及（7.38±1.23）分。Gleason 6分、7分以及≥8分分别占37.7%、34.3%以及28.0%。患者年龄〈60岁组占10.5%（71/674）,60-69岁组占30.6%（206/674）,70-79岁组占47.6%（321/674）,≥80岁组占11.3%（76/674）。患者年龄与GS具有显著相关性（r^2=0.013,P=0.003）,与主要分级具有显著相关性（r^2=0.014,P=0.002）,与次要分级无显著有相关性（r^2=0.005,P=0.055）。结论：在前列腺腺癌患者中≥70岁者所占比例较高;GS≥7分所占比例较高;但年龄与GS具有相关性,年龄对GS的预测价值不大。
Objective： To investigate the correlation between age and Gleason score （GS） in patients with prostate adenocarci- noma. Methods： This study included 674 patients with pathologically confirmed prostate adenocarcinoma. We determined the GS, primary grade, and secondary grade of the cases, and compared them among different age groups. Results ： The mean age of the patients was （70.22 ± 8.26） yr, ranging from 25 to 96 years, （69.06 ± 8.35） yr in those with GS 6, （70.55 ± 8.16） yr in GS 7, （70.99 ± 6.54） yrinGS8, （71.56±9.18） yrinGS9, and （72.79±11.36） inGS 10. The mean GS, primary grade, and secondary grade were 7.08 ±1.09, 3.54 ±0.72, and 3.53±0.66, respectively, and the mean GSs in the 〈60 yr, 60 -69 yr, 70-79 yr, and ≥ 80 yr groups were 6. 86 ± 1.10,6.99 ±1.10,7.08 ±1.04, and 7.38 ±1.23, respectively. Those withGS 6, 7, and ≥ 8 accounted for 37.7% , 34.3% , and 28.0% , respectively. The patients aged 〈 60, 60 - 69, 70 - 79, and 〉t 80 years constituted 10.5% （71/674）, 30.6% （206/674）, 47.6% （321/674）, and 11.3% （76/674）, respectively. The age of the patients was significantly correlated with GS （r^2 = 0.013, P = 0. 003 ） and the primary grade （r^2 = 0. 014, P = 0.002）, hut not the secondary grade （ r^2 = 0. 005, P = 0.055 ）. Conclusion ： Of the prostate adenocarcinoma patients, those aged ≥ 70 years form a larger proportion, and those with GS ≥ 7 comprise a higher percentage. The age of the patient is correlated with Gleason score but has a limited value in its prediction.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2015年第2期140-143,共4页
National Journal of Andrology
