摘要
目的：探讨首发重度抑郁症患者血清中促炎物质IL-1α、IL-6、IL-18、肿瘤坏死因子（ TNF-α）以及血清总补体活性（ CH50）水平的变化，以期对首发抑郁症的诊断有所帮助。方法采用汉密尔顿抑郁量表（HAMD）对首发抑郁症患者进行抑郁评分，采用酶联免疫吸附法（ELISA）检测49例首发重度抑郁症组患者和40例体检健康人正常对照组其血清中IL-1α、IL-6、IL-18、TNF-α及CH50的水平。结果首发重度抑郁症患者血清中IL-6、IL-18、TNF-α及CH50水平与正常对照组差异有统计学意义（P＜0．05），而IL-1α则无明显差异（P＞0．05）；在首发重度抑郁症男女性别分组中，血清中IL-1α水平差异有统计学意义（P＜0．05），IL-6、IL-18、TNF-α及CH50水平差异无统计学意义（P＞0．05）。结论细胞因子IL-6、IL-18、TNF-α及CH50可能参与或伴随首发重度抑郁症的发生和发展，可以作为首发重度抑郁症的辅助诊断指标。
Objective To provide supportive evidences for the diagnosis of primary major depres-sive disorder （MDD） by analyzing the alterations of proinflammatory cytokines such as IL-1α, IL-6, IL-18, TNF-αas well as the total complement activity （CH50） in serum samples.Methods Hamilton Depression Rating Scale （ HAMD） was used to rate the severity of depression with the patients who were diagnosed as primary MDD.Enzyme-linked immunosorbent assay （ELISA） was used to detect the levels of IL-1α, IL-6, IL-18 and TNF-αand the CH50 in serum samples from 49 patients and 40 healthy subjects .Results Pa-tients with MDD showed significantly different levels of IL-6, IL-18, TNF-αand CH50 in serum samples as compared with that in healthy subjects （P〈0.05）.No significant difference with the level of IL-1αwas ob-served between the patients with MDD and healthy subjects （P〉0.05）.There were significant gender differ-ences with levels of IL-1αamong the patients with MDD （P〈0.05）.However, no significant differences with the levels of IL-6, IL-18, TNF-αand CH50 were found between male and female patients （P〉0.05）. Conclusion The changes of CH50 and certain proinflammatory cytokines such as IL-6, IL-18 and TNF-αmight be involved in the progression of MDD , suggesting the possibility of using them as indicators for the di-agnosis of MDD.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2015年第1期33-36,共4页
Chinese Journal of Microbiology and Immunology
基金
贵州省科教青年英才培养工程资助项目[黔省专合字（2012）194号]
关键词
首发重度抑郁症
细胞因子
CH50
Primary major depressive disorder
Cytokine
IL-1α
IL-6
IL-18
TNF-α
CH50
