摘要
目的：探讨多灶性胃癌患者的临床病理特征及预后。方法回顾性分析南京大学医学院附属鼓楼医院2003年1月至2014年3月收治的30例多灶性胃癌患者的临床资料，并随机选取同一时期收治的100例单灶性胃癌患者作为对照，比较两组患者临床病理特征及预后。结果30例多灶性胃癌中3个或3个以上病灶者6例（20．0％）。多灶性胃癌组患者诊断年龄较单灶性胃癌组轻[（56．8±16．4）岁比（63．3±10．8）岁，P＜0．05]。多灶性胃癌组肿瘤病理分期以Ⅰ期为主（73．3％，22／30），而单灶性胃癌组则以Ⅲ期为主（64.0％，64／100）。多灶性胃癌组与单灶性胃癌比较，肿瘤相对较小，且神经侵犯和脉管浸润的比例亦明显较低（均P＜0．01）。多灶性胃癌术后5年生存率明显高于单灶性胃癌组（76．0％比48．8％，P＜0．05），与单灶性胃癌组相似，多灶性胃癌患者的预后与肿瘤大小、神经侵犯、脉管浸润、肿瘤浸润深度、淋巴结转移及TNM分期有关（均P＜0．05）；两组患者不同临床病理因素情况下的5年生存率差异均无统计学意义（均P＞0．05）。结论多灶性胃癌患者肿瘤分期较早，总体预后优于单灶性胃癌。
Objective To study the clinicopathological features and prognosis of multifocal gastric cancer. Methods Clinicopathological data of 30 cases with multifocal gastric cancer from January 2003 to March 2014 in our department were retrospectively analyzed. Random selection of 100 cases of single focal gastric cancer patients admitted in the same period was used as control group. Clinicopathological features and prognosis were compared between two groups. Results Six（20.0%） multifocal gastric cancer patients had 3 or more focuses with different differentiation degrees at the same time. The age of multifocal gastric cancer patients was younger than that of single focal gastric cancer [（56.8±16.4） year vs. （63.3±10.8） year, P〈0.05]. The TNM stage of multifocal gastric cancer was mainly stageⅠ（73.3%, 22/30）, and the TNM stage of single focal gastric cancer was mainly stage Ⅲ （64.0%, 64/100）. As compared to single focal gastric cancer group, multifocal gastric cancer group had smaller tumors, lower ratio of nerve invasion and lymphatic vascular invasion （all P〈0.01）. Five-year survival rate was higher in multifocal gastric cancer group as compared to single focal gastric cancer group （76.0% vs. 48.8%, P〈0.05）. The prognosis of multifocal gastric cancer patients was associated with tumor size, nerve invasion, vascular invasion, depth of tumor invasion, lymphatic metastasis and TNM staging （all P〈0.05）, which was similar to single focal gastric cancer patients. Differences of 5-year survival rate under various clinicopathological＆amp;nbsp;conditions were not significant between two groups （all P〉0.05）. Conclusion Multifocal gastric cancer patients have earlier staging tumor and overall advantage as compared to those with single focal gastric cancer.
出处
《中华胃肠外科杂志》
CAS
CSCD
北大核心
2015年第2期135-138,共4页
Chinese Journal of Gastrointestinal Surgery
基金
吴阶平院士基金（320.6750.13118）
关键词
胃肿瘤
多原发癌
临床病理特征
预后
Stomach neoplasms
Multiple primary cancers
Clinicopathological characteristics
Prognosis
