摘要
目的探讨多原发癌（multiple primary cancers,MPC）的发病特点、早期诊断、治疗和预后,以期提高对多原发癌的诊治水平。方法对我院1998年1月至2008年12月收治的65例MPC患者的临床资料进行回顾性分析。结果研究期间,在10 834例恶性肿瘤患者中发现MPC 65例,MPC的总体发生率为0.6%（65/10 834）。其中,双重癌发生率为0.4%（46/10 834）,三重癌发生率为0.1%（16/10 834）,四重癌发生率为0.02%（3/10 834）。发病间隔时间在3年以内者有13例,在3~5年者有22例,最长间隔时间为35年。首发癌和重复癌均以消化系统肿瘤最常见,其次是乳腺癌、泌尿生殖系统肿瘤及头颈部肿瘤。所有患者经病理学检查均为恶性肿瘤,经外科手术或放、化疗后的3年生存率为65%,5年生存率为40%。结论加强对MPC发病规律的认识,做到早期诊断、积极治疗,可延长生存期、改善预后。
Objective To explore characteristics,early diagnosis,treatment and prognosis of multiple primary cancers（MPC） in order to promote its diagnosis and therapy. Methods Sixty-five MPC cases in our hospital from Jan.1998 to Dec.2008 were studied retrospectively. Results Sixty-five MPC cases were found in 10 834 cases with malignant tumors,and the incidence of MPC was 0.6%（65/10 834）,in which the incidences of duplex primary cancers,triple primary cancers and quadruple primary cancers were 0.4%（46/10 834）,0.1%（16/10 834） and 0.02%（3/10 834）,respectively.Thirteen cases had the interval no more than 3 years between the first occurrence and the recurrence,and 22 cases had the interval of 3-5 years.The longest interval was 35 years.Primary cancer and repetitive cancer occurred most frequently in digestive system with the next in breast,genitourinary system and head and neck.The 3-year and 5-year survival rate were 65% and 40%,respectively. Conclusions The mechanism and development of MPC should be researched further.Early diagnosis and active treatment can prolong the survival span and improve prognosis of MPC patients.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2010年第5期591-593,共3页
Fudan University Journal of Medical Sciences
关键词
多原发癌
诊断
治疗
预后
multiple primary cancers
diagnosis
treatment
prognosis
