摘要
目的:探讨血液灌流联合血液透析对尿毒症患者钙磷代谢及皮肤瘙痒症状的影响。方法:选择42例尿毒症患者为研究对象。将42例患者按照随机数字表法分为观察组和对照组。观察组18例,接受血液透析联合血液灌流治疗;对照组24例,接受单纯血液透析治疗。比较两组治疗前后钙、磷、皮肤瘙痒情况及生活质量。结果:治疗4、8周后观察组钙磷乘积明显较治疗前改善(P<0.01),且较同期对照组改善明显,差异有统计学意义(P<0.01);治疗4、8周后观察组血清磷水平明显较治疗前改善(P<0.01),且较同期对照组改善明显,差异有统计学意义(P<0.01)。治疗后4、8周观察组皮肤瘙痒情况明显较治疗前好转,且较同期对照组患者皮肤瘙痒情况改善明显,差异有统计学意义(P<0.001);治疗后观察组生活质量明显高于对照组,差异有统计学意义(P<0.001)。结论:血液灌流联合血液透析可有效纠正尿毒症患者血钙磷代谢紊乱,明显减轻患者皮肤瘙痒症状。
Objective：To study influence of blood perfusion combined with hemodialysis on calcium and phosphorus metabolism and skin pruritus symptoms of patients with uremia. Method：42 uremia patients were selected as the research object.According to random number table method 42 patients were randomly divided into observation group and control group. Observation group：18 patients,treated with hemodialysis combing blood perfusion;Control group：24 cases,pure hemodialysis therapy. Calcium,phosphorus,skin pruritus conditions and quality of life of two groups before and after the treatment were compared. Result：4 weeks,8 weeks after treatment,serum calcium level of observation group was obviously improved than before the treatment（P〈0.01）,and the control group improved significantly during this period,and there were statistically significant difference（P〈0.01）;4 weeks,8 weeks after treatment,serum phosphorus levels of observation group was obviously improved before the treatment（P〈0.01）,and the control group improved significantly during this period,and there were significant difference（P〈0.01）. 4 weeks and 8 weeks after treatment skin pruritus in observation group were significantly better than before treatment,and also improved obviously than skin pruritus condition of patients in the control group at the same period,and there were statistically significant difference（P〈0.001）.The quality of life after treatment in observation group was obviously higher than that of control group,and the difference was statistically significant（P〈0.001）.Conclusion：Blood perfusion combined with hemodialysis can effectively correct uremia patients’ blood calcium and phosphorus metabolism disorder,and significantly reduce patients’ skin pruritus symptoms.
出处
《中国医学创新》
CAS
2015年第5期1-4,共4页
Medical Innovation of China
关键词
尿毒症
血液灌流
血液透析
疗效
Uremia Blood perfusion Hemodialysis Curative effect
