摘要
目的：对南京医科大学第二附属医院抗菌药使用情况和葡萄球菌属的耐药情况进行统计分析，为临床合理使用抗菌药提供参考依据。方法：对我院2010～2012年抗菌药的用药频度（DDDs）及所分离的葡萄球菌属的药敏结果分别进行统计分析。结果：2010～2012年我院抗菌药的DDDs分别为357978．3，379699．9和264053．4。3年共分离葡萄球菌3228株，未发现耐万古霉素、利奈唑胺菌株，出现了少数替考拉宁耐药菌株。3年来葡萄球菌属的耐药率总体呈下降趋势，金黄色葡萄球菌对万古霉素、替考拉宁、利奈唑胺、呋喃妥因的耐药率在0～0．93％之间，略低于凝固酶阴性葡萄球菌的耐药率（0～2．3％），仍高度敏感；凝固酶阴性葡萄球菌对红霉素、左氧氟沙星、苯唑西林、复方磺胺甲嗯唑耐药率分别为79．8％，58．8％，72．8％，44．1％，高于金黄色葡萄球菌对这四种药的耐药率60．8％，42．1％，60．0％，26．2％。金黄色葡萄球菌对呋喃妥因和替考拉宁的耐药率与头孢菌素类药DDDs呈正相关；凝固酶阴性葡萄球菌对庆大霉素耐药率与大环内酯类药DDDs，对米诺环素耐药率与青霉素类药DDDs、氨基糖苷类药DDDs，对利福平耐药率与糖肽类药DDDs之间，对苯唑西林耐药率与硝基咪唑类药DDDs均呈正相关。结论：3年来葡萄球菌属的耐药率虽然有所波动，但总体呈下降趋势，与抗菌药的使用减少有一定的关系。
Objective：To probe into the utilization of antibiotics, and to understand drug resistance of Staphylo- coccus in our hospital in order to provide reference for clinical rational use of antibiotics. Methods： The DDDs of antibiotics in the inpatients and the drug resistance rate of staphylococcus were analyzed in our hospital from 2010 to 2012. Results ：The DDDs of antibiotics from 2010 to 2012 were 357 978.3,379 699.9,264 053.4 respectively. A total number of 3 228 Staphylococcus were isolated. No staphylococcal strains were found resistant to vaneomyein or linezolid. But a few staphylo- coccal strains were found resistant to teieoplanin. Generally the resistance rate of staphylococcus got lower from 2010 to 2012. The resistance rates of staphylococcus aureus to vancomyein, teieoplanin, linezolid and nitrofurantoin varing from 0 to 0.93% were a little lower than those of eoagulase-nagetive staphylococcus varing from 0 to 2.3%. The strains of staphylo- coccus aureus were still highly susceptible to vancomyein, teieoplanin, linezolid and nitrofurantoin. The resistance rates of Coagulase-nagetive staphylococcus to erythomyein, Levofloxacin, oxazocilline and SMZ-TMP were 79.8%, 58.8%, 72.8% ,44.1% respectively,higher than those of staphylococcus aureus 60.8% ,42.1% ,60.0% ,26.2%. The consump- tion of Cephalosporins was positively correlated with the resistance of staphylococcus aureus to nitrofurantoin and teicoplanin. A positive correlation was found between the consumption of Macrolides and the resistance of coagulase-nagetive staphylococ- cus to Gentamicin, the consumption of penieillins, aminoglycosides and the resistance of eoagulase-nagetive staphylococcus to minoeycline, the consumption of Glyeopeptides and the resistance of coagulase-nagetive staphylococcus to rifampicin, the consumption of Nitroimidazoles and the resistance of coagulase-nagetive staphylococcus to oxaeillin. Conclusion： Although the resistance rate of staphylococcus varied in the 3 years, in general itg getting lower, and is somewhat r
出处
《药物流行病学杂志》
CAS
2015年第1期28-32,共5页
Chinese Journal of Pharmacoepidemiology
基金
2010年度南京医科大学第二附属医院青年科技启动基金(编号:QN201005)
