摘要
细胞内病原体感染是临床抗感染治疗面临的严峻挑战。现阶段,临床上抗胞内菌感染治疗的常用策略是长周期使用高剂量抗菌药物,这不仅给患者带来了严重的不良反应,也给全社会造成了巨大的经济压力。因此,开发新策略使在体外试验中显示良好杀菌效果的抗菌药物更好地杀灭胞内菌显得尤为重要。用适当的载体将药物包埋或包封能够更好地控制其药物动力学行为,能够有效提高抗菌药物胞内抗菌的有效生物利用度。本文就近年来抗胞内菌的靶向载药系统的研究进行综述。
Infection of intracellular pathogens remains a serious challenge for clinical anti-infective treatment. The most commonly used strategy for the treatment of intracellular bacteria is long-term use of antimicrobials at high concentration, which not only brings se- rious side effects to patients, but also causes great economic pressure to the whole society. Thus, the development of new strategies to better kill intracellular bacteria by the antimicrobials which showed good bactericidal effect in in vitro experiments is extremely important. With appropriate carriers to embed or encapsulate drugs can better control drugs' pharmacokinetic behavior resulting in effective bioavailability increase of antimicrobials. The current studies on targeted drug delivery systems for anti-intracellular bacteria were re- viewed in the paper.
出处
《中国药师》
CAS
2017年第11期2057-2060,共4页
China Pharmacist
关键词
抗胞内菌
载药体系
抗菌药物
靶向
Anti-intracellular bacteria
Drug delivery system
Antimicrobials
Targeting