摘要
目的探讨参麦注射液对乳腺癌吡柔比星化疗的心肌保护作用。方法选择患者80例,随机分为两组各40例,两组患者均使用吡柔比星,对照组服用辅酶Q和维生素E,观察组使用参麦注射液,比较两组患者心电图改变及心肌酶和心肌肌钙蛋白变化情况。结果观察组发生窦性心动过速、室性或房性期前收缩、ST-T段改变以及室性心动过速的比率显著低于对照组(P<0.05或0.01),观察组治疗后肌酸激酶和肌酸激酶同工酶水平显著低于对照组(P<0.01),同时肌钙蛋白I和肌钙蛋白T显著低于对照组(P<0.01)。结论参麦注射液能有效减少乳腺癌使用吡柔比星化疗的心脏毒性,减少心电图异常表现,值得临床重视。
Objective To investigate the protective effect of Shenmai injection for cardiac muscle of breast cancer patients who underwent pirarubicin chemotherapy. Methods 80 patients were randomly divided into control group and observation group with 40 cases in each group. Both groups were treated with pirarubicin. The control group were given coenzyme Q and vitamin E,while the observation group were given Shenmai injection. Then,electrocardiogram changes as well as myocardial enzyme and cardiac troponin changes of the two groups were compared. Results Incidence rates of sinus tachycardia,ventricular premature contraction / premature atrial contraction,ST-T change and ventricular tachycardia of the observation group were significantly lower than those of the control group（ P〈0. 05 or 0. 01）. After treatment,levels of creatine kinase and creatine kinase isoenzyme MB as well as troponin I and troponin T of the observation group were significantly lower than those of the control group（ P〈0. 01）. Conclusion Shenmai injection can effectively reduce cardiotoxicity of breast cancer patients who undergo pirarubicin chemotherapy,and reduce abnormalities of ECG. Thus,it is worthy of attention in clinic.
出处
《右江医学》
2014年第6期669-671,共3页
Chinese Youjiang Medical Journal
关键词
参麦注射液
乳腺癌
吡柔比星
心肌保护药物
Shenmai injection
breast cancer
pirarubicin
myocardial protection medicine
