摘要
目的:探讨参麦注射液对化疗后女性乳腺癌患者的心脏保护作用。方法:897例新疆乳腺癌患者随机分为对照组(436例)和治疗组(461例),对照组给予环磷酰胺、阿霉素、5-氟尿嘧啶化疗(CAF方案),治疗组在对照组基础上加用参麦注射液,总疗程6个月。观察2组患者化疗前后心电图、动态心电图及心肌酶谱的变化。结果:治疗组较对照组能降低乳酸脱氢酶、肌酸激酶、肌钙蛋白(P<0.05)及心电图、动态心电图的阳性发生率(P<0.05)。结论:参麦注射液有显著的预防化疗所致的心肌损伤作用。
Objective： To investigate the myocardium protective effects of Shenmai injection to Xinjiang women with breast cancer who also receiving combined chemotherapy.Method：The total of 897 patients with breast cancer were randomly divided into control group（n=436） and treatment group（n=461）.Control group were given cyclophosphamide,adriamycin and 5-fluorouracil（CAF） chemotherapy,while treatment group were added Shenmai injection basing on the control group,six cycles as the course of treatment.The changes of electrocardiogram,dynamic electrocardiography and myocardium enzymology were observed.Result：Shenmai injection can decreased the level of LDH,CK and cTNT and positive rate of electrocardiogram dynamic electrocardiography after chemotherapy.Conclusion：Shenmai injection can protect myocardium injury caused by CAF chemotherapy.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2011年第2期138-141,共4页
Journal of Clinical Cardiology
关键词
乳腺肿瘤
5-氟尿嘧啶
参麦注射液
心肌保护
breast cancer
5-fluorouracil
myocardial damage
shenmai injection
myocardial protective
