摘要
目的:运用Meta分析方法研究CCND1基因G870A位点多态性与宫颈癌易感性的发生风险。方法:检索Pub Med和CNKI数据库中有关CCND1基因G870A位点多态性与宫颈癌易感性的相关性研究,根据纳入标准提取文献数据,应用STATA 11.0软件以OR值和95%可信区间为效应指标,进行Meta统计分析,并对发表偏倚及检测敏感性进行检测。结果:纳入9篇对照研究,共计2638例宫颈癌患者和3651例健康对照人群,Meta分析结果显示,总人群中,CCND1基因G870A位点多态性与宫颈癌风险之间没有显著关联(GA vs GG:OR=1.07,95%CI=0.86-1.34,P=0.53,I2=57.6%;AA vs GG:OR=1.09,95%CI=0.79-1.51,P=0.59,I2=75.0%;(GA+AA)vs GG:OR=1.08,95%CI=0.86-1.36,P=0.49,I2=64.6%;AA vs(GG+GA):OR=1.07,95%CI=0.83-1.36,P=0.61,I2=73.3%)。在针对种族和对照人群来源设计的亚组分析中,仍没有发现CCND1基因G870A位点多态性和宫颈癌的发生风险具有相关性。结论:CCND1基因G870A位点多态性可能与宫颈癌的发生无关。
Objective：To investigate the association between CCND1 G870A polymorphism and cervical cancer risk by using Meta-analysis. Methods：The relevant literatures were searched. The data of genotype distributions and other information were extracted in the groups of patients and healthy control,Odds ratio（ OR）with 95% confidence interval（CI）,publish bias and sensitive analysis was perfoymed with STATA 11. 0 software. Results：Nine published case-control studies were selected,including 2638 patients with cervical cancer and 3651 controls. Overall,no signif-icant association between CCND1 G870A polymorphism and cervical cancer risk was found in this Meta -analysis （GA vs GG：OR=1. 07,95%CI=0. 86-1. 34,p=0. 53,I2 =57. 6%;AA vs GG：OR=1. 09,95%CI=0. 79-1. 51, p=0. 59,I2 =75. 0%;（GA＋AA）vs GG：OR=1. 08,95%CI=0. 86-1. 36,p=0. 49,I2 =64. 6%;AA vs（GG＋GA）：OR=1. 07,95%CI=0. 83-1. 36,p=0. 61,I2 =73. 3%）. In the subgroup analysis ethnicity and study de-sign,no significant association was detected in other genetic models. Conclusion：This Meta-analysis demonstrates that CCND1 G870A polymorphism may be not a risk factor for cervical cancer.
出处
《现代肿瘤医学》
CAS
2015年第1期112-115,共4页
Journal of Modern Oncology
