摘要
目的:探讨前哨淋巴结活检(SLNB)阳性乳腺癌患者非前哨淋巴结(NSLN)转移的危险因素。方法:收集2009年7月—2013年10月新疆医科大学附属肿瘤医院收治的138例SLNB阳性的乳腺癌患者临床资料,采用单因素及多因素Logistic回归分析方法研究各项临床病理因素与NSLN转移的关系。结果:单因素分析显示,原发肿瘤直径、组织学分级、前哨淋巴结转移率、前哨淋巴结转移灶最大径及脉管浸润与NSLN转移有关(均P<0.05);多因素Logistic回归分析发现,原发肿瘤直径(OR=2.263,P=0.005)、前哨淋巴结转移率(OR=1.919,P=0.002)、前哨淋巴结转移灶最大径(OR=8.479,P=0.000)、脉管浸润(OR=4.518,P=0.029)是NSLN转移的独立危险因素。结论:原发肿瘤直径、前哨淋巴结转移率、前哨淋巴结转移灶最大径及脉管浸润可作为预测乳腺癌NSLN转移的独立性指标。
Objective： To investigate the risk factors for non-sentinel lymph node （NSLN） metastasis in breast cancer patients with positive sentinel lymph node biopsy （SLNB） results.Methods： The clinical data of 138 breast cancer patients with positive SLNB results admitted from July 2009 to October 2013 at the affiliated tumor hospital of Xinjiang Medical University were collected. The relations of the clinicopathologic factors with NSLN metastasis were determined by univariate and multivariate Logistic regression analysis.Results： Univariate analysis showed that primary tumor diameter, histological grade, rate of sentinel lymph node metastases, maximal diameter of the sentinel lymph node metastases and vessel invasion were related to NSLN metastasis （all P〈0.05）; Logistic regression analysis identified that primary tumor diameter （OR=2.263, P=0.005）, rate of sentinel lymph node metastases （OR=1.919, P=0.002）, maximal diameter of the sentinel lymph node metastases （OR=8.479, P=0.000） and vessel invasion （OR=4.518, P=0.029） were independent risk factors for NSLN metastasis.Conclusion： Primary tumor diameter, rate of sentinel lymph node metastases, maximal diameter of the sentinel lymph node metastases, and vessel invasion can be used as independent variables to predict NSLN metastasis in breast cancer patients.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2014年第5期661-664,共4页
China Journal of General Surgery
