摘要
目的:探讨Toll样受体-4(TLR4)及细胞毒T淋巴细胞相关抗原-4(CTLA-4)在高血压患者外周血中的表达及临床意义。方法:选择高血压患者35例和健康人20例,使用流式细胞仪检测所有被研究者外周血TLR4的表达水平,用ELISA法检测CTLA-4的表达情况。结果:高血压患者的外周血TLR4表达率为(8.63±1.16)%,显著高于对照组(5.27±1.25)%,差异具有统计学意义(t=6.16,P<0.05);高血压患者的外周血CTLA-4表达水平高于对照组(P<0.05);高血压患者CTLA-4阳性率与TC、LDL-C呈正相关(P<0.05);TLR4与CTLA-4值呈正相关(r=0.886,P<0.05)。结论:TLR4及CTLA-4在高血压患者中高表达,与高血压的发生有关。
Objective To investigate the expression and significance of Peripheral blood of Toll-like receptor-4 and cytotoxic T lymphocyte-associated antigen-4 in patients with essential hypertension. Methods We selected 35 patients with hypertension and 20 healthy people.We used flow cytometry to investigate TLR4 expression levels, and ELISA to detect the expression of CTLA-4. Results TLR4 expression in peripheral blood of patients with hypertension was （8.63＋1.16）%, significantly higher （5.27±1.25）%.The difference was statistically significant （t = 6.16,P 〈 0.05）; CTLA-4 expression in peripheral blood of patients with hypertension was significantly higher （P 〈 0.05） ; Hypertensive patients with CTLA-4 positive rate and TC, LDL-C was positively correlated （P〈0.05） ; TLR4 and CTLA-4 was positive correlation （r = 0.886, P 〈 0.05）. Conclusions TLR4 and CTLA-4 were high expression in hypertensive patients with hypertension, and related to hypertension.
出处
《实用医学杂志》
CAS
北大核心
2014年第22期3601-3603,共3页
The Journal of Practical Medicine
