摘要
促红细胞生成素(erythropoietin,EPO)不仅具有促红细胞生成作用,更是一种多组织分布、具有组织保护作用的多功能细胞因子。近年来,越来越多科学家注意到EPO的抗抑郁潜能,并提出可作为新型抗抑郁的选择性药物。该文概括了EPO在抗抑郁效应的基础及实验研究,并阐述了其可能机制及其临床应用前景,旨在对EPO在抑郁症中的研究及应用现状有一个系统认识。
Erythropoietin （EPO）,which is routinely used in clinic to treat anemia,has been implicated in a wide range of activities on diverse tissues.Recently,accumulating evidence shows that EPO has antidepressant-like effects and may be a po-tential drug candidate for treating mood symptoms and memory dysfunction in depression.This review summarizes the current＆amp;nbsp;progress on EPO’s antidepressant-like effects,and explores its potential mechanism and clinical application in the future,provi-ding a general view of the research and application status of EPO in depression.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第12期1635-1638,共4页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展计划(973计划)资助项目(No2011CB505106)
关键词
促红细胞生成素
抑郁症
神经再生
抗炎
抗凋亡
衍生物
erythropoietin
depression
neuranagenesis
anti-inflammatory
anti-apoptosis
derivative
