摘要
目的:探讨术前化疗、放疗联合手术综合方案治疗口腔中晚期鳞癌的临床效果。方法:对经病理确诊的104例口腔中晚期鳞癌患者行术前化疗、放疗1周期,再行联合根治手术。并对患者术后局部复发率、远处转移率、生存率、生活质量、张口度及钛板排斥、感染、断裂等情况进行临床观察。结果:口腔中晚期鳞癌术前化疗、放疗总有效率达98.08%,手术切除率达100%,术后不良反应轻,局部复发率1.92%(2例),远处转移率2.88%(3例),出现钛板排斥、感染反应导致张口受限2.88%(3例)。术后患者5年生存率91.35%(95例)。结论:术前化疗、放疗产生积极的抗肿瘤作用,取得满意的临床效果,为进一步手术治疗提供了良好的基础。术前化疗、放疗联合手术综合方案治疗中晚期口腔鳞癌,可提高患者远期生存率,手术切除率,术后不良反应轻。
Objective： To investigate the clinical effect of the integrated program of preoperative chemotherapy , ra- diotherapy combined with surgery to cure middle-late squamous cell carcinoma of oral. Method： A total of 104 biopsy con- firmed cases from our hospital, were included in this research. The patients needed to accept preoperative chemotherapy and the radiotherapy for 1 cycle. And then the combined radical operations started. The clinical effect was researched in aspects of local recurrence rate, distant metastasis rate, survival rate, quality of life, mouth opening, and titanium rejection, infection, fracture and so on. Result： The effective rate of preoperative chemotherapy and radiotherapy to treat middle-late squamous cell carcinoma of oral was 98.08%.The rate of surgery resection after preoperative induced chemotherapy and preoperative radiotherapy was 100 % with less postoperative adverse reactions. The local recurrence rate was only 1.92 % （2 cases）. The distant metastasis rate was only 2.88 % （3 cases）. The rate of titanium rejection and infection reaction that leads to restric- tion of mouth opening was only 2.88 % （3 cases）. The 5-year survival rate after operation was 91.35 % （95 cases）. Cnclu- sion： Preoperative chemotherapy and radiotherapy have a good clinical effect in positive anti-tumor, providing a good founda- tion for further surgical treatment.The integrated program of preoperative induced chemotherapy, preoperative radiotherapy combined with surgery can raise the long-term survival rate, surgery resection rate and has little adverse reactions.It would be worthy of disseminating and applying for the comprehensive treatment of middle-late squamous cell carcinoma of oral and maxillofacial region.
出处
《临床口腔医学杂志》
2014年第10期619-622,共4页
Journal of Clinical Stomatology
关键词
口腔
鳞癌
中晚期
术前化疗
术前放疗
oral and maxillofacial region
squamous cell carcinoma： middle-late
preoperative induced chemothera-py
preoperative radiotherapy
