摘要
目的探讨尿视黄醇结合蛋白(RBP)、转铁蛋白(TRF)及Ⅳ型胶原检测在糖尿病肾病(DN)早期诊断中的临床价值。方法 80例糖尿病(DM)患者根据是否并发肾病分为DM组38例和DN组42例,另选择健康志愿者30例作为对照组,对3组对象的尿RBP、TRF及Ⅳ型胶原水平进行检测。结果 DN组患者尿RBP、TRF和Ⅳ型胶原水平显著高于DM组和对照组,差异均有统计学意义(P<0.05);DM组患者尿Ⅳ型胶原水平显著高于对照组,差异均有统计学意义(P<0.05);DM组患者尿RBP和TRF水平与对照组比较差异均无统计学意义(P>0.05)。结论尿RBP、TRF及Ⅳ型胶原联合检测可作为DN的早期诊断指标。
Objective To investigate the clinical value of urinary retinol binding protein（ RBP）, transferrin（TRF） and type IV collagen detection in the early diagnosis of diabetic nephropathy （DN）. Methods A total of 80 patients with diabetes mellitus（DM） were divided into DM group（38 cases） and DN group（42 cases） according to whether they complicated with kidney disease;in the same time ,30 healthy volunteers were selected as control group. The levels of RBP,TRF and type Ⅳ col- lagen in urine were detected in the three groups. Results The levels of urinary RBP,TRF and type Ⅳ collagen in DN group were significantly higher than those in DM group and control group （ P 〈 0.05 ）. The level of urinary type Ⅳ collagen in DM group was significantly higher than that in control group（ P 〈 O. 05 ）. There was no significantly difference in the levels of urinary RBP and TRF between DM group and control group （P 〉 0.05）. Conclusion Urinary RBP,TRF and type Ⅳ collagen combined detection can be used as the early diagnostic marker for DN.
出处
《新乡医学院学报》
CAS
2014年第10期823-824,共2页
Journal of Xinxiang Medical University
关键词
视黄醇结合蛋白
转铁蛋白
Ⅳ型胶原
糖尿病肾病
retinol binding protein
transferrin
type Ⅳ collagen
diabetic nephropathy
