摘要
目的:探讨血清、尿视黄醇结合蛋白(Retinolbindingprotein,RBP)水平在肝肾综合征鉴别诊断中的价值。方 法:采用ELISA法测定90例肝硬化患者和26例健康体检者的血清、尿RBP水平,同时检测其血肌酐及尿肌酐,算 出校正的24h肌酐清除率作为肾小球滤过率标准。结果:肝肾综合征组的血清、尿RBP水平均明显降低(P均< 0.01);单纯肝硬化组的血清RBP水平明显低于对照组(P<0.01),而尿RBP水平与对照组相比无显著性差异(P >0.05)。结论:联合检测血清、尿RBP对肝肾综合征的鉴别诊断有重要意义。
Objective: To investigate the differential diagnostic value of serum retinol binding protein (RBP) and urinary RBP in patients with hepatorenal syndrome (HRS). Methods: Ninety patients with liver cirrhosis were investigated and divided into Group 1-simple liver cirrhosis group (creatitnine clearance (Ccr)≥40 ml/min 1.73 m -2,n=71) and Group 2-HRS group (Ccr<40 ml/min 1.73 m -2,n=19).According to Child-pugh classification, 26,40 and 24 patients were in Group A,B and C respectively. Serum RBP , urinary RBP, serum creatinine (Scr) and urinary creatinine (Ucr) of them were assayed and compared with those of 26 healthy persons as control group. Serum RBP and urinary RBP were measured by ELISA. Results: Serum (RBP) and urinary RBP concentration were significantly lower in patients with HRS than that in control group (P<0.01); Serum RBP level in Group 1 was significantly lower than that in controls (P< 0.01), while there were not significant difference in urinary RBP between two groups. Conclusions: The combination of low serum RBP and low urinary RBP may be more helpful in the differential diagnosis of HRS.
出处
《实用临床医学（江西）》
CAS
2005年第3期7-9,共3页
Practical Clinical Medicine
关键词
视黄醇结合蛋白
肝肾综合征
鉴别诊断
retinol binding protein
hepatorenal syndrome
differential diagnosis
