摘要
目的探讨血浆同型半胱氨酸(Hcy)水平与阿尔茨海默病(AD)的相关性。方法检测100例AD患者与30例正常老年人血浆Hcy浓度,采用简易精神状况量表(MMSE)对两组进行认知功能评定并与血浆Hcy浓度进行相关性研究。结果AD组血浆Hcy浓度高于正常对照组,有非常显著性差异(t=6.74,P<0.01);AD组MMSE评分与血浆Hcy浓度呈负相关(r=-0.79,P<0.01)。结论高Hcy血症可能是AD危险因素,该研究为AD早期干预提供了依据。
Objective To explore the relationship between plasma homocysteine levels and Alzheimer ＇s disease （ AD） .Methods Plasma homocysteine levels of 100 cases of AD and 30 cases of healthy aged people were detected .Mini Mental State Examination （ MMSE） was used to assess dementia status .Correlation analysis was used to explore the relationship between the MMSE score and the plasma homocysteine levels of 30 AD patients ,the same as the control group .Results Plasma Hcy levels in patients with AD were higher than that of normal control group ,the difference was statistically significant （t=6.74,P〈0.01）;There was a negative correlation between MMSE score and plasma Hcy levels in patients with AD （r=-0.79,P〈0.01）.Conclusion Hyperhomocysteinemia may be a risk factor for AD,this study provides the basis for early intervention of AD .
出处
《中国健康心理学杂志》
2014年第10期1485-1486,共2页
China Journal of Health Psychology
基金
无锡市科技指导性计划项目(编号:CSZOON1235)
