摘要
目的:通过Meta分析的方法对轻度认知功能障碍(mild cognitive impairment,MCI)与血浆同型半胱氨酸(homocysteine,Hcy)浓度的关联性进行评价。方法:计算机检索PubMed、BIOsis Previews、Medline、EBSCO、CBM、CNKI、维普、万方等数据库2003-2013年公开发表的国内外相关文献,对检索到的文献进行质量评价和资料提取后,采用RevMan 5.2软件进行Meta分析。结果:共纳入11篇合格文献,包括737例病例和866例对照。病例组Hcy水平高于对照组,其合并标准化均数差值及其95%CI为0.92(0.57,1.27),漏斗图显示基本对称。结论:血浆Hcy浓度的升高可能是MCI发病的危险因素,但其病因关联性仍有待于在人群中开展大规模队列研究和随机对照实验研究进一步深入论证。
Objective ：To evaluate the association between mild cognitive impairment（MCI） and plasma homocysteine （Hcy） level through Meta analysis. Methods：Published literatures at home and abroad from 2003 to 2013 were searched through large literature databases, including PubMed, BIOsis Previews, Medline, EBSCO, CBM, CNKI, etc. The quality of studies was evaluated and data were extracted from studies.RevMan 5.2 software was used to do Meta analysis. Results：Eleven qualified control studies were identified, including 737 patients and 866 controls. The pooled standardized mean difference and 95% confidence interval of Hcy concentrations was 0.92（0.57, 1.27）,indicating higher Hcy levels in MCI patients. Funnel plot was symmetrical in general. Conclusions：Higher concentration of plasma Hcy may be a risk factor of MCI. Prospective studies in the risk of developing MCI are needed, preferably in the form of cohort study and randomized controlled trials in large population.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2014年第2期207-211,共5页
Journal of Chongqing Medical University
基金
重庆市科学技术委员会资助项目(编号:cstc2011jjA10021)
