摘要
目的探讨影响颈动脉内中膜增厚及斑块形成患者尤其伴有2型糖尿病者的相关危险因素。方法对405例住院患者进行颈动脉彩色多普勒超声检测,根据颈动脉IMT将其分为3组:A组:IMT正常组(IMT<0.9mm)、B组:IMT增厚组(1.0mm-1.2mm)、C组:颈动脉硬化斑块形成组(IMT>1.2mm或者有斑块形成),比较三组人群临床特点差异,并对其中129例伴有2糖尿病患者IMT增厚及斑块形成相关危险因素进行logistic回归分析。结果 C组高血压和糖尿病患病率明显高于A组,同时SBP,BMI,FBG和TG水平亦明显增高于A组。Logistic回归分析显示2型糖尿病患者FBG(95%CI:1.03-1.98,OR=1.23,P=0.04)和尿酸水平(95%CI:1.01-2.68,OR=1.57,P=0.02)与颈动脉IMT增厚及斑块形成明显相关。结论颈动脉IMT增厚及斑块形成者心脑血管高危因素患病率明显高于IMT正常组。FBG和尿酸水平是2型糖尿病患者颈动脉硬化及颈动脉IMT增厚的危险因素。
Objective To study the influence factors of carotid intima-media thickness and plaques, especially in patients with type 2 diabetes patients.Methods 405 inpatients were enrolled and carotid artery Doppler ultrasound was detected. Samples were divided into 3 groups： group A： normal IMT group （IMT〈0.9mm） , group B： IMT thickness group （1.0mm to 1.2mm） and group C： carotid thickness or plaque formation group （IMT〉1.2mm or plaque formation） . Clinical characteristics were analyses and multivariate logistic regression analysis assessed the association the predictors for thickening of IMT and plaque formation in 129 type 2 diabetes patients.Results The prevalence of hypertension, diabetes in group C were significantly higher than group A.SBP, BMI, FBG and TG levels were also obviously higher in group C. Logistic regression analysis showed that FBG （OR=1.23,P=-0.04） and uric acid levels （OR=1.57,P=0.02） were overtly related to thickening and plaque formation in patients with type 2 diabetes.Conclusion Prevalence of cardiovascular risk factors in patients with carotid IMT thickness or plaque was more popular than IMT normal group. Age, diabetes duration and uric acid levels are risk factors for carotid IMT thickening and plaques in type 2 diabetes patients.
出处
《云南医药》
CAS
2014年第5期517-519,共3页
Medicine and Pharmacy of Yunnan
基金
云南省教育厅科学研究基金一般项目(2011Y181)
