摘要
目的:比较、评价纳米碳混悬液与亚甲蓝应用于腹腔镜结直肠癌根治术前哨淋巴结标记的差异、优劣及其临床应用价值。方法:将50例结直肠癌患者随机分为两组,分别于腹腔镜结直肠癌根治术中采用纳米碳、亚甲蓝进行前哨淋巴结定位活检,记录两种方法检出前哨淋巴结的数量及分布情况,比较两组检出总淋巴结数及前哨淋巴结检测的成功率、准确性、敏感性、特异性、假阴性率。结果:两组患者一般资料差异无统计学意义(P>0.05)。纳米碳组平均检出淋巴结(16.1±1.02)枚,明显多于亚甲蓝组(12.7±1.10,P=0.025)。纳米碳组23例检出前哨淋巴结,共43枚,平均(1.87±0.18)枚;亚甲蓝组20例检出前哨淋巴结,共23枚,平均(1.15±0.11)枚,两组差异有统计学意义(P=0.002)。纳米碳组前哨淋巴结检出成功率、准确性、敏感性、特异性、假阴性率等均优于亚甲蓝组,但差异无统计学意义(P>0.05)。结论:腹腔镜结直肠癌根治术中使用纳米碳混悬液进行前哨淋巴结活检效果明显优于亚甲蓝,且有助于淋巴结的清扫,并指导病理分期。
Objective： To compare and evaluate the differences,advantages and disadvantages of carbon nanoparticle suspension and methylene blue for sentinel lymph node labeling in laparoscopic colorectal cancer radical surgery,and explore their clinical values.Methods： Fifty patients with colorectal cancer were randomly divided into two groups. For each group,carbon nanoparticle or methylene blue was used for sentinel lymph node detection in laparoscopic colorectal cancer radical surgery. The sentinel lymph node number and distribution were recorded. The total lymph node number,the sentinel lymph node detection rate,accuracy,sensitivity,specificity,and false negative rate were compared between the two groups. Results： The patients＇ general characteristics were comparable between the two groups（ P 0. 05）. The mean lymph node cleared in the carbon nanoparticle group was（ 16. 1 ± 1. 02）,which was significantly more than that of the methylene blue group（ 12. 7 ± 1. 10）（ P = 0. 025）. In the carbon nanoparticle group,43 sentinel lymph nodes were detected in 23 patients,the mean number was（ 1. 87 ± 0. 18）; In the methylene blue group,23 sentinel lymph nodes were detected in 20 patients,the mean number was（ 1. 15 ± 0. 11）. There was significant difference between the two groups（ P = 0. 002）. For the carbon nanoparticle group,the sentinel lymph node detection rate,accuracy,sensitivity,specificity,and false negative rate were all superior than those of the methylene blue group,but the difference was not statistically significant（ P 0. 05）. Conclusions： In laparoscopic colorectal cancer radical surgery,sentinel lymph node labeling with carbon nanoparticle is obviously superior to methylene blue. Besides,carbon nanoparticle positioning could also instruct lymph node clearance and pathological classification.
出处
《腹腔镜外科杂志》
2014年第9期673-676,共4页
Journal of Laparoscopic Surgery
关键词
结直肠肿瘤
腹腔镜检查
前哨淋巴结
纳米碳
亚甲蓝
Colorectal neoplasms
Laparoscopy
Sentinel lymph node
Carbon nanoparticle
Methylene blue
