摘要
本文采用微量波动试验,枯草杆菌重组修复试验和小鼠骨髓嗜多染红细胞微核试验检测了三氯甲烷的致突变性。结果表明:三氯甲烷既不引起碱基置换突变,也不引起移码突变,但在一定剂量范围内可引起小鼠骨髓嗜多染红细胞微核形成率明显增高,且有剂量-效应关系,从而提示三氯甲烷是一种染色体断裂剂。
It, this paper, the mutagenesis of trichloromethane(TCM) was studied by using microtitre fluctuation test, bacillus suhtilis REC repair test and micronucleus test of bone marrow PCE of mice. The results showed that TCM caused neither base-pairs substitution mutagenesis nor framshift mutagenesis. the enhancement of micronucleus rates and dose effect relationship were found in certain dose range. Therefore, it is suggested that TCM is a kind of clastogen.
关键词
三氯甲烷
致突变
Mutagenesis Micronucleus Bacillus subtilis Trichloromethane
