摘要
目的：探讨血浆D-二聚体和同型半胱氨酸（ Hcy）在慢性心力衰竭患者中的表达意义。方法90例慢性心力衰竭患者作为观察组，90例健康人作为对照组。测定两组血D-二聚体、Hcy和脑钠肽（ BNP）水平。结果观察组血D-二聚体、Hcy和BNP均明显高于对照组（P﹤0.01）。血浆D-二聚体与BNP呈正相关（P﹤0.05），血浆Hcy与BNP呈正相关（P﹤0.05）。所有患者常规治疗14 d，1例治疗无效死亡，其余89例治疗后血D-二聚体、Hcy和BNP均明显降低（P﹤0.01）。观察组平均随访6个月，死亡7例，死亡组血D-二聚体、Hcy和BNP均明显高于对照组（P﹤0.05或P﹤0.01）。结论血浆D-二聚体和Hcy可以用于慢性心力衰竭患者的病情诊断，判断患者预后，指导治疗。
Objective To study the expression of plasma D-dimer and homocysteine（ Hcy）in patients with chronic heart failure. Methods Ninety patients with chronic heart failure were enrolled into the observation group and 90 healthy people were enrolled into the control group. D-dimer,Hcy and brain natriuretic peptide（ BNP）in the two groups were detected. Results Blood D-dimer,Hcy and BNP in the observation group were significantly higher than those in the control group（P﹤0. 01）. BNP and plasma D-dimer had a positive correlation（P﹤0. 05）. BNP and Hcy had a positive correlation（P﹤0. 05）. Conventional treatment for all patients through 14 d,14 d in the treatment of one patient died,and the levels of D-dimer,Hcy and BNP were significantly decreased in the remaining 89 patients after treatment（P﹤0. 01）. Observation group were followed up for an average of 6 months,7 patients died,and the levels of D-dimer,Hcy and BNP in the death group were significantly higher than those in the control group（P﹤0. 05 or P﹤0. 01）. Conclusions Plasma D-dimer and Hcy can be used to diagnose the disease in patients with chronic heart failure,determine prognosis and guide treatment.
出处
《中国实用医刊》
2014年第19期48-50,共3页
Chinese Journal of Practical Medicine
