摘要
肌少症，亦称骨骼肌减少症（sarcopenia）或者说是增龄性骨骼肌减少，是以骨骼肌质量、力量以及功能的降低为主要特征的退行性综合征。肌少症的发生机制复杂多样，包括运动量下降、神经-肌肉功能衰退及运动单位重组、蛋白质摄入与合成减少、激素水平变化、脂肪组织增加与慢性炎症反应、细胞凋亡、骨骼肌线粒体功能紊乱及基因与种族等。深入研究肌少症的发病机理对老年人肌少症的防治具有重要意义。
Sarcopenia, also known as age-related sarcopenia,is defined as adegenerativesyndrome characterized by progressive and generalized loss of skeletal muscle mass, strength and function. Sarcopeniainvolves complex mechanisms, including exercise lacking, neuromuscular function decline and motor unit restructuring, declining in adequate protein intake and synthesis, changingin hormonelevels,expansionoffattissue and chronic inflammation, apoptosis, skeletal muscle mitochondrial dysfunction, and different genes and ethnics,et al.Further studyonthe mechanisms of sarcopeniais of greatsignificancein the prevention and treatment of geriatric sarcopenia.
出处
《中华老年多器官疾病杂志》
2014年第8期637-640,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
肌少症
老年人
机制
sarcopenia
elderly
mechanism
