摘要
目的探讨血浆N端脑利钠肽前体(N-terminal precursor of brain-type natriuretic peptide,NT-proBNP)在老年慢性充血性心力衰竭(chronic congestive heart failure,CHF)诊断中的价值及与心功能的关系。方法选择83例CHF患者和60例健康体检者,采用化学发光免疫分析法检测血浆NT-proBNP水平,超声心动图检测患者心脏结构和功能改变。结果 CHF组血浆NT-proBNP水平(1643.3±756.7 pg/ml)显著高于健康体检者(46.2±11.4 pg/ml),差异有统计学意义(P<0.05);而且,随着病情的进展,血浆NT-proBNP含量逐渐升高(P<0.05)。结论血浆NT-proBNP水平与CHF患者的心力衰竭程度正相关,在临床CHF病人诊断和分级中具有重要的作用。
Objective To explore the diagnosis value of plasma N-terminal precursor of brain-type natriuretic peptide（NTproBNP） in elderly patients with chronic congestive heart failure（CHF） patients and its relation with cardiac function. Methods The levels of plasma NT-proBN were detected by Chemiluminescence Immunoassay in 83 patients with CHF and 60 healthy controls. The changes of heart structure and function were measured by echocardiogram. Results The level of NT-proBNP in CHF group（1643.3±756.7 pg/ml） was significantly higher than that in health control group（46.2±11.4 pg/ml）（P〈0.05）. With the aggravation of CHF, the levels of NT-proBNP increased gradually（P〈0.05）. Conclusion The level of plasma NT-proBNP is positively correlated with the degree of CHF, and may play an important role in clinical diagnosis and classification of CHF.
出处
《实验与检验医学》
CAS
2014年第5期498-499,共2页
Experimental and Laboratory Medicine
基金
国家自然科学基金面上项目(编号:81371300)
