摘要
目的:研究抗精子抗体(antisperm antibody,AsAb)在不孕不育患者血清中的表达情况,探讨AsAb的临床意义。方法:采用抗精子抗体ELISA试剂盒检测238例不孕不育患者血清中的AsAb。结果:实验组238例不孕不育患者中,AsAb阳性56例,阴性182例,阳性率23.5%;正常对照组86例中,AsAb阳性7例,阴性79例,阳性率8.1%。实验组AsAb阳性率明显高于对照组(χ2=9.55,P<0.01)。结论:AsAb是引起免疫性不孕不育的重要因素,可能成为设计免疫避孕策略的潜在干预靶点。
Objective： To research the expression of antisperm antibody （AsAb） in serum of infertile patients, explore the clinical significance of AsAb. Methods： AsAb ELISA kit was used to detect serum AsAb level in 238 infertile patients. Results： In experimental group （238 infertile patients） , 56 patients were found with positive AsAb, 182 patients were found with negative AsAb, the positive rate was 23. 5% ; in control group （86 cases）, 7 cases were found with positive AsAb, 79 cases were found with negative AsAb, the positive rate was 8. 1%. The positive rate of AsAb in experimental group was statistically significantly higher than that in control group （x^2 = 9. 55, P 〈 0. 01 ） . Conclusion ： AsAb is an important factor which induces immune infertility, it may become an interference target of immunological contraception.
出处
《中国妇幼保健》
CAS
北大核心
2014年第26期4298-4299,共2页
Maternal and Child Health Care of China
关键词
不孕不育
免疫学
抗精子抗体
Infertility
Immunology
Antisperm antibody
