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克罗恩病发病机制的研究进展 被引量：5

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摘要 克罗恩病（Crohn＇s disease,CD）是一种以慢性肉芽肿性炎性病变为表现的非特异性肠炎,目前多认为CD与自身免疫缺陷、感染、遗传等因素有关,可累及全胃肠道,全壁层炎症,节段性分布.胃肠道以外的器官如关节、皮肤、眼及肝胆胰等也可累及[1].CD是炎症性肠病（inflammatory bowel disease,IBD）的一种亚型,目前认为它是一个涉及多基因的复杂疾病,本质上为遗传易感个体在肠内微生物触发下发生的持续性和异常的炎症反应,其中黏膜免疫具有重要作用.对不同人种的IBD发病率、家族聚集现象及双生子的研究发现,IBD具有遗传易感性[2].
作者 魏慧 王爱英
机构地区 北京大学第三医院消化科
出处 《临床消化病杂志》 2014年第4期249-251,共3页 Chinese Journal of Clinical Gastroenterology
关键词 克罗恩病 基因 肠黏膜 免疫反应 肠道微生物
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献27

  • 1MATHEW C G.New links to the pathogenesis of Crohn disease provided by genome-wide association scans[J].Nat Rev Genet,2008,9:9-14. 被引量：1
  • 2谢娜娜,巴亚斯.古楞,任建林.克罗恩病的遗传易感性相关发病机制研究进展[J].中国医药指南,2012,10(20):73-75. 被引量：2
  • 3McGOVERN D P,BARRETT J C.Genome-wide metaanalysis increases to 71 the number of confirmed Crohn' s disease susceptibility loci[J].Nat Genet,2010,42:1118-1125. 被引量：1
  • 4ANDERSON C A,BOUCHER G,LEES C W,et al.Meta-analysis identifies 29 additional ulcerative colitis risk loci,increasing the number of confirmed associations to 47[J].Nat Genet,2011,43:246-252. 被引量：1
  • 5CARTER M J,LOBO A J,TRAVIS S P.Guidelines for the management of inflammatory bowel disease in adults[J].Gut,2004,53 (Suppl 5):Ⅴ1-16. 被引量：1
  • 6MUISE A M,WALTERS T D,GLOWACKA W K,et al.Polymorphisms in E-cadherin (CDH1) results in a mis-localised cytoplasmic protein that is associated with Crohn' s disease[J].Gut,2009,58:1121-1127. 被引量：1
  • 7HASSAN S W,DOODY K M,HARDY S,et al.Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse[J].PLoS One,2010,5:e8868-8868. 被引量：1
  • 8DAESIGNY M,BABEU J P,DUPUIS A A,et al.Loss of hepatocyte-nuclear-factor-4α affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice[J].PLoS One,2009,4:e7609-7609. 被引量：1
  • 9PICKERT G,NEUFERT C,LEPKES M,et al.STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing[J].J Exp Med,2009,206:1465-1472. 被引量：1
  • 10WEHKAMP J,STANGE E F.Paneth' s disease[J].J Crohns Colitis,2010,4:523-531. 被引量：1

二级参考文献29

  • 1Carter MJ,Lobo AJ,Travis SP.Guidlines for the management of inflammatory bowel disease in adults[J].Gut,2004,53(Suppl 5):V1-V16. 被引量：1
  • 2APDW2004 Chinese IBD Working Group.Retrospective analysis of 515 cases of Crohn’s disease hospitalization in Chain:nationwide study from 1990 to2003[J].J Gastroenterol Hepatol,2006,21(6):1009-1015. 被引量：1
  • 3McGovern DP,Barrett JC.Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci[J].Nature Genet,2010,42(12):1118-1125. 被引量：1
  • 4Anderson,Boucher G,Lees CW,et al.Meta-analysis identifies 29 additional ulcerative colitis risk loci,increasing the number of confirmed associations to 47[J].Nat Genet,2011,43(3):246-252. 被引量：1
  • 5Muise AM,Walters TD,Glowacka WK,et al.Polymorphisms in E-cadherin(CDH1)result in a mis-localised cytoplasmic protein that is associated with Crohn’s disease[J].Gut,2009,58(8):1121-1127. 被引量：1
  • 6Hassan SW,Doody KM,Hardy S,et al.Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse[J].PLoS ONE,2010,5(1):e8868. 被引量：1
  • 7Darsigny M,Babeu JP,Dupuis AA,et al.Loss of hepatocyte-nuclear-factor-4αaffects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice[J].PLoS ONE,2009,4(10):e7609. 被引量：1
  • 8Pabst O.,Zweigerdt R,Arnold HH.Targeted disruption of thehomeobox transcription factor Nkx2-3in mice results in postnatal lethality and abnormal development of small intestine and spleen[J].Development,1999,126(10):2215-2225. 被引量：1
  • 9Pickert G,Neufert C,Leppkes M,et al.STAT3links IL-22signaling in intestinal epithelial cells to mucosal wound healing[J].J Exp Med,2009,206(7):1465-1472. 被引量：1
  • 10Cadwell K,Liu JY,Brown SL,et al.A key role for autophagy and the autophagy gene Atg16l1in mouse and human intestinal Paneth cells[J].Nature,2008,456(7219):259-263. 被引量：1

共引文献3

同被引文献53

  • 1黄荣.用美沙拉嗪治疗克罗恩病的疗效观察[J].当代医药论丛,2014,12(10):134-135. 被引量：3
  • 2张芹.母乳——充饥之外的功效[J].中国保健食品,2001,14(10):46-46. 被引量：1
  • 3叶天士.临证指南医案[M].上海：上海人民出版社,1959.224—226. 被引量：76
  • 4MARSHALL J K,CAW&ON R,z EALHY I,et al.prospetive comparison of small bowel meal with pneumocolon versus ileocolonoscopy diagnosis disease[J].American Journal of Gastroenterology,2004,99(7):1321-1329. 被引量：1
  • 5MAY G R,SUTHERLAND L R,MEDDINGS J B.Is small intestinal permeability really increased in relatives of patients with Crohn's disease[J].Gastroenterology,1993,104(6):1627-1632. 被引量：1
  • 6KUME K,YAMASAKI M,TASHIRO M,et al.Activations of coagulation and fibrinolysis secondary to bowel inflammation in patients with ulcerative colitis[J].Internal Medicine,2007,46(17):1323-1329. 被引量：1
  • 7MIEHSLER W,REINISCH W,VALIC E,et al.Is inflammatory bowel disease an Independent and disease specific risk factor for thromboembolism[J].Gut,2004,53(4):542-548. 被引量：1
  • 8GRAINGE M J,WEST J,CARD T R.Venous thromboembolism during active disease and remission in inflammatory bowel disease:a cohort study[J].Lancet,2010,375(9715):657-663. 被引量：1
  • 9TALBOT R W,HEPPELL J,DOZOIS R R,et al.Vascular complications of inflammatory bowel-disease[J].Mayo Clinic Proceedings,1986,61(2):140-145. 被引量：1
  • 10JACKSON L M,O'GORMAN PJ,O'CONNELL J,et al.Thrombosis in inflammatory bowel disease:clinical setting,procoagulant profile and factor V Leiden[J].QJM,1997,90:183-188. 被引量：1

引证文献5

二级引证文献32

临床消化病杂志
2014年 第4期

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