摘要
目的了解住院艾滋病（AIDS）患者的生存情况及其影响因素,探讨延长AIDS患者生存时间的策略。方法对2010-01-2012-12住院的305例AIDS患者的临床资料进行回顾性分析,采用COX比例风险模型分析影响生存率的危险因素。结果截止研究终点,305例患者中,死亡204例（66.9%）,存活101例（33.1%）。第1-3个月的累积生存率分别为45%、25%、11%,中位生存时间为27.4 d。多因素COX比例风险模型分析结果显示,感染途径为性传播和其他途径的死亡风险比静脉吸毒低（HR=0.878,HR=0.373）,基线CD4^＋T淋巴细胞计数较高者的死亡风险比较低者低（HR=0.157,HR=0.423）,入院时抗病毒治疗者死亡风险较低（HR=0.378）;入院时合并发热者（HR=3.033）、合并AIDS相关性脑病者（HR=1.678）死亡风险较高。结论 AIDS住院患者的住院生存时间相对较短,感染途径、基线CD4^＋T淋巴细胞计数、入院时是否合并发热、是否合并AIDS相关性脑病,以及是否抗病毒治疗是影响住院生存时间的主要因素。
Objective To understand the survival situation and its influencing factors in patients with AIDS,to explore the strategy prolonging the survival time of patients with AIDS. Methods Clinical data of 305 of AIDS patients from January 2010 to December 2012 were retrospectively analyzed,and the COX proportional hazard model was used to analyze the risk factors affecting survival rate. Results At the end point of the study,of 305 patients,204 patients（ 66. 9%） died,101 patients（ 33. 1%） survived. At 1 - 3 months the cumulative survival rates were45%,25%,11% respectively. The median survival time was 27. 4 d. Multivariate COX proportional hazard model analysis showed that the risk of death in patients were infected via sexual transmission and other ways was lower than that in patients were infected via intravenous route（ HR = 0. 878,HR = 0. 373）. The risk of death in patients with higher baseline of CD4＋T lymphocyte count was lower than that in patients with lower baseline of CD^4＋T lymphocyte count（ HR = 0. 157,HR = 0. 423）. The patients received antiviral treatment at admission had lower risk of death（ HR =0. 378）; The patients with fever（ HR = 3. 033）,and associated encephalopathy（ HR = 1. 678） at admission had higher risk of death. Conclusion AIDS hospitalization survival time is relatively short,the route of infection,baseline of CD4^＋T lymphocyte count,whether fever at admission,whether merger AIDS-associated encephalopathy,and whether use the antiviral treatment is the main factors influencing the survival time of hospitalization.
出处
《中国临床新医学》
2014年第8期687-691,共5页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西卫生厅科研课题(编号:Z2012025)
关键词
艾滋病
住院时间
死亡原因
影响因素
AIDS
Hospital stays
Cause of death
Influence factors
