摘要
利奈唑胺为新型噁唑烷酮类抗菌药物,可用于耐药革兰阳性菌感染。因其由非肝药酶途径代谢,利奈唑胺说明书提示轻、中度肝功能不全者无须调整剂量,重度肝功能不全者尚未有相关研究。本文分析、总结了利奈唑胺在肝功能受损患者中的应用情况。
Linezolid is an oxazolidninone, which is indicated to the infection of resistant Gram-positive bacteria. Due to its nonrenal and nonenzymatic clearance pathways, the label of linezolid suggests that no dose adjustment is recommended to patients with mild-to-moderate hepatic impairment and its use in severe hepatic impairment has not been evaluated. This paper analyzed and summarized the use of linezolid in hepatic impairment patients.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2014年第8期559-562,共4页
Chinese Journal of New Drugs and Clinical Remedies
