摘要
由于抗生素的广泛应用导致其耐药菌大量产生,探索新的抗耐药性的革兰阳性菌药物已成为国内外医药界的研究热点。噁唑烷酮类抗菌药是一类新型化学全合成抗菌药,具有抑制多重耐药革兰阳性菌的作用。现在主要利用芳基异氰酸酯法、伯胺不对称拆分法、氧羰酰芳胺和(R)-丁酸缩水甘油酯法、不对称合成法以及催化偶合合成法完成噁唑烷酮合成。
Since the extensive use of antibiotics resulted in the wide spread of drug-resistant bacteria, many research scientists in medical field have focused on the development of new antibiotics possessing the bioactivity of anti-gram positive pathogens. Totally-synthetic oxazolidinones are a new class of antibacterial agents for the treatment of the infections caused by gram-positive bacteria including the multidrug-resistant pathogens. Recent progress in total synthesis of oxazolidinones was reviewed.
出处
《国外医药（抗生素分册）》
CAS
2009年第2期82-88,共7页
World Notes on Antibiotics
