摘要
长期过度饮酒可以导致机体的一系列改变,对于骨骼的健康也是不利的。酒精对于成人骨骼是不利的,能够抑制骨形成,相对增加骨吸收。酒精对于成长中的骨骼也是不利的,能够影响骨峰值,增加骨质疏松发病率,使骨质疏松发生提前。酒精对骨骼的影响主要通过酒精对于营养、骨骼激素、性激素、骨骼细胞、细胞内信号泵系统等作用影响骨骼健康。酒精导致低钙血症、低镁血症、血磷酸盐过多、活性维生素D水平减低;酒精使血中降钙素水平升高、甲状旁腺素水平减低或增高、皮质醇水平增高;酒精可使睾酮及雌激素减少;酒精使成骨细胞活性损伤,破骨细胞活性正常;酒精直接干预1型胰岛素样生长因子受体(IGF-IR)而影响骨形成。因此,酒精性骨病的典型特征是抑制骨形成而有相对于正常的骨吸收。
The long-term excessive drinking can lead to a series of changes in the body, is unfavorable for bone health. Alcohol is bad for the adult skeletal, to inhibit bone formation, increased bone resorption. Alcohol for the growth of bone is bad, can affect the peak bone mass, increase the prevalence of osteoporosis. The effects of alcohol on bone mainly through alcohol for the role of nutrition, hormone, sex hormone, bone cells, intracellular signal pump system affects bone health. Specific performance in alcohol induced hypomagnesemia, hypocalcemia, hyperphosphatemia, active vitamin D level decreased; alcohol makes calcitonin levels in blood increased, decreased or increased levels of parathyroid hormone, cortisol level increased; alcohol can make testosterone and estrogen decrease; alcohol makes the activity of osteoblasts injury, the activity of osteoclasts normal; alcohol directly intervene in the type 1 insulin-like growth factor receptor （IGF-IR） and the effect of bone formation. Therefore, the typical characteristics of alcoholic bone is impaired bone formation and bone resorption relative to normal.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2014年第7期858-862,共5页
Chinese Journal of Osteoporosis
